参见 鉴别诊断 以获取更多具体信息
几乎所有急性呼吸性酸中毒的病因都可发展成为危及生命的情况。这些患者最需关注的是即将发生的呼吸衰竭。对呼吸性酸中毒的初步急救处理时不考虑病因,而是即刻评估患者的基本情况(气道、通气、心血管情况),并通过第二次全面调查快速确认可能的病因。
初步评估
一旦确诊为呼吸性酸中毒,首要目标是确保患者的生命体征稳定,必要时开放气道、保证通气或循环支持。
对于有反应迟钝、血液动力学不稳定性或呼吸肌疲劳证据(辅助肌的使用、呼吸困难、呼吸急促)的患者,在开展进一步调查研究之前,患者需要机械通气支持并且将患者转移至有监护的床位(例如重症监护病房)。[5]Royal College of Physicians, British Thoracic Society, Intensive Care Society. Non-invasive ventilation in chronic obstructive pulmonary disease: management of acute type 2 respiratory failure. Concise Guidance to Good Practice series, No 11. October 2008. http://www.brit-thoracic.org.uk/ (last accessed 7 June 2017).https://www.rcplondon.ac.uk/sites/default/files/concise-niv-in-copd-2008.pdf[6]British Thoracic Society. BTS/ICS Guidelines for the ventilatory management of acute hypercapnic respiratory failure in adults. March 2016. https://www.brit-thoracic.org.uk/ (last accessed 7 June 2017).https://www.brit-thoracic.org.uk/standards-of-care/guidelines/btsics-guidelines-for-the-ventilatory-management-of-acute-hypercapnic-respiratory-failure-in-adults/应当完成缺氧评估,并且根据临床指征补氧。[1]O'Driscoll BR, Howard LS, Earis J, et al. BTS guideline for oxygen use in adults in healthcare and emergency settings. Thorax. 2017;72(suppl 1):ii1-ii90.https://www.brit-thoracic.org.uk/document-library/clinical-information/oxygen/2017-emergency-oxygen-guideline/bts-guideline-for-oxygen-use-in-adults-in-healthcare-and-emergency-settings/http://www.ncbi.nlm.nih.gov/pubmed/18838559?tool=bestpractice.com
进一步评估
一旦患者病情稳定,应开始对呼吸性酸中毒严重病因进行评估,容许对个别根本原因进行即刻特异性的治疗。
应当考虑的实验室检查包括以下方面:
根据所怀疑的病因,影像学检查包括以下方面:
呼吸性酸中毒的治疗可包括通气支持(有创或无创)和进一步根据病理生理学特点进行特殊药物治疗。[3]Ram FS, Picot J, Lightowler J, et al. Non-invasive positive pressure ventilation for treatment of respiratory failure due to exacerbations of chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2004;(3):CD004104.http://onlinelibrary.wiley.com/o/cochrane/clsysrev/articles/CD004104/frame.htmlhttp://www.ncbi.nlm.nih.gov/pubmed/15266518?tool=bestpractice.com[6]British Thoracic Society. BTS/ICS Guidelines for the ventilatory management of acute hypercapnic respiratory failure in adults. March 2016. https://www.brit-thoracic.org.uk/ (last accessed 7 June 2017).https://www.brit-thoracic.org.uk/standards-of-care/guidelines/btsics-guidelines-for-the-ventilatory-management-of-acute-hypercapnic-respiratory-failure-in-adults/[7]Epstein SK, Singh N. Respiratory acidosis. Respir Care. 2001;46:366-383.http://www.ncbi.nlm.nih.gov/pubmed/11262556?tool=bestpractice.com