最常见的病因是专业医疗人员在进行阴茎检查、安置导尿管或膀胱镜检查期间,未割包皮的男性阴茎包皮回缩后忽略复位包皮至龟头上方。[3]Choe JM. Paraphimosis: current treatment options. Am Fam Physician. 2000;62:2623-2626, 2628.http://www.aafp.org/afp/2000/1215/p2623.htmlhttp://www.ncbi.nlm.nih.gov/pubmed/11142469?tool=bestpractice.com卫生状况差和细菌感染(龟头炎)反复发作的情况下会使该病情更可能发生的几率增加。发生包皮嵌顿的其他原因包括:患有包茎(包皮口狭窄)未环切包皮的男性进行性交的过程中、引起包皮收缩的各种性行为、阴茎体环、寄生虫感染、苔藓样硬化症、包皮环切不充分或阴茎血管瘤。[4]Verma S. Coital penile trauma with severe paraphimosis. J Eur Acad Dermatol Venereol. 2005;19:134-135.http://www.ncbi.nlm.nih.gov/pubmed/15649211?tool=bestpractice.com[5]Ramdass MJ, Naraynsingh V, Kuruvilla T, et al. Case report. Paraphimosis due to erotic dancing. Trop Med Int Health. 2000;5:906-907.http://www.ncbi.nlm.nih.gov/pubmed/11169281?tool=bestpractice.com[6]Yiqiter M, Arda IS, Hicsonmez A. An unusual cause of paraphimosis: hemangioma of the glans penis. J Pediatr Surg. 2008;43:e31-e33.http://www.ncbi.nlm.nih.gov/pubmed/18280267?tool=bestpractice.com大约 29% 的患者一旦包皮水肿消退后有包茎的迹象。[7]Reynard JM, Barua JM. Reduction of paraphimosis the simple way - the Dundee technique. BJU Int. 1999;83:859-860.http://www.ncbi.nlm.nih.gov/pubmed/10368214?tool=bestpractice.com