体征/症状 在使用药物后的 5-20 天出现皮疹,病程拖延,无前驱斑,皮损更可能为亮红或紫色,瘙痒严重。[7]Gonzalez LM, Allen R, Janniger CK, et al. Pityriasis rosea: an important papulosquamous disorder. Int J Dermatol. 2005;44:757-764.http://www.ncbi.nlm.nih.gov/pubmed/16135147?tool=bestpractice.com
药物史包括近期使用:血管紧张素转化酶抑制剂、阿司匹林(乙酰水杨酸)、别嘌醇、砷、巴比妥类、β-受体阻滞剂、铋、可乐定、d-青霉胺、金、氢氯噻嗪、异维 A 酸、左旋咪唑、甲丙氨酯、美索丙嗪、甲硝唑、尼美舒利、非甾体抗炎药、奥美拉唑、柳氮磺胺吡啶、特比萘芬、酪氨酸激酶抑制剂、白喉类毒素和 BCG/乙型肝炎病毒/肺炎球菌疫苗。[2]Dyer JA. Childhood viral exanthems. Pediatr Ann. 2007;36:21-29.http://www.ncbi.nlm.nih.gov/pubmed/17269280?tool=bestpractice.com[3]Trager JD. What's your diagnosis? Scaly pubic plaques in a 2-year-old girl - or in an "inverse" rash. J Pediatr Adolesc Gynecol. 2007;20:109-111.http://www.ncbi.nlm.nih.gov/pubmed/17418397?tool=bestpractice.com[6]Chuh A, Zawar V, Lee A. Atypical presentations of pityriasis rosea: case presentations. J Eur Acad Dermatol Venereol. 2005;19:120-126.http://www.ncbi.nlm.nih.gov/pubmed/15649208?tool=bestpractice.com[7]Gonzalez LM, Allen R, Janniger CK, et al. Pityriasis rosea: an important papulosquamous disorder. Int J Dermatol. 2005;44:757-764.http://www.ncbi.nlm.nih.gov/pubmed/16135147?tool=bestpractice.com[16]Chuh A, Lee A, Chan PK. Pityriasis rosea in pregnancy - specific diagnostic implications and management considerations. Aust N Z J Obstet Gynaecol. 2005;45:252-253.http://www.ncbi.nlm.nih.gov/pubmed/15904457?tool=bestpractice.com[17]Brazzelli V, Prestinari F, Roveda E, et al. Pityriasis rosea-like eruption during treatment with imatinib mesylate: description of 3 cases. J Am Acad Dermatol. 2005;53(suppl 1):S240-S243.http://www.ncbi.nlm.nih.gov/pubmed/16227099?tool=bestpractice.com[18]Atzori L, Pinna AL, Ferreli C, et al. Pityriasis rosea-like adverse reaction: review of the literature and experience of an Italian drug-surveillance center. Dermatol Online J. 2006;12:1.http://escholarship.org/uc/item/80d8301dhttp://www.ncbi.nlm.nih.gov/pubmed/16638369?tool=bestpractice.com[19]Scheinfeld N. Imatinib mesylate and dermatology part 2: a review of the cutaneous side effects of imatinib mesylate. J Drugs Dermatol. 2006;5:228-231.http://www.ncbi.nlm.nih.gov/pubmed/16573254?tool=bestpractice.com
检查 组织病理学与药疹诱发的真皮嗜酸性粒细胞增多更相符。[18]Atzori L, Pinna AL, Ferreli C, et al. Pityriasis rosea-like adverse reaction: review of the literature and experience of an Italian drug-surveillance center. Dermatol Online J. 2006;12:1.http://escholarship.org/uc/item/80d8301dhttp://www.ncbi.nlm.nih.gov/pubmed/16638369?tool=bestpractice.com