症状消除:(证据质量中等):制霉菌素治疗 1 至 4 周完全消除口角炎,比安慰剂更有效。[18]Ohman SC, Jontell M. Treatment of angular cheilitis. The significance of microbial analysis, antimicrobial treatment and interfering factors. Acta Odontol Scand. 1988;46:267-272.http://www.ncbi.nlm.nih.gov/pubmed/3063051?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
症状消除:(证据质量中等):制霉菌素治疗 1 至 4 周完全消除口角炎,比安慰剂更有效。[18]Ohman SC, Jontell M. Treatment of angular cheilitis. The significance of microbial analysis, antimicrobial treatment and interfering factors. Acta Odontol Scand. 1988;46:267-272.http://www.ncbi.nlm.nih.gov/pubmed/3063051?tool=bestpractice.com
预防:(证据质量中等):与安慰剂相比,嚼含木糖醇或醋酸氯己定和木糖醇的口香糖降低了老人的口角炎发病率。[22]Simons D, Brailsford SR, Kidd EA, et al. The effects of medicated chewing gums on oral health in frail older people; a 1-year clinical trial. J Am Geriatr Soc. 2002;50:1348-1353.http://www.ncbi.nlm.nih.gov/pubmed/12164990?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
预防:(证据质量中等):与安慰剂相比,嚼含木糖醇或醋酸氯己定和木糖醇的口香糖降低了老人的口角炎发病率。[22]Simons D, Brailsford SR, Kidd EA, et al. The effects of medicated chewing gums on oral health in frail older people; a 1-year clinical trial. J Am Geriatr Soc. 2002;50:1348-1353.http://www.ncbi.nlm.nih.gov/pubmed/12164990?tool=bestpractice.com
症状控制:(几乎无证据证明):患者满意于在口角接合处的裂缝注射胶原蛋白。[20]Pinski KS, Coleman WP III. Microlipoinjection and autologous collagen. Dermatol Clin. 1995;13:339-351.http://www.ncbi.nlm.nih.gov/pubmed/7600710?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
症状控制:(几乎无证据证明):患者满意于在口角接合处的裂缝注射胶原蛋白。[20]Pinski KS, Coleman WP III. Microlipoinjection and autologous collagen. Dermatol Clin. 1995;13:339-351.http://www.ncbi.nlm.nih.gov/pubmed/7600710?tool=bestpractice.com
症状控制:(几乎无证据证明):患者满意于对口角炎进行口腔修复治疗。[21]Lu DP. Prosthodontic management of angular cheilitis and persistent drooling: a case report. Compend Contin Educ Dent. 2007;28:572-577.http://www.ncbi.nlm.nih.gov/pubmed/18018392?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
症状控制:(几乎无证据证明):患者满意于对口角炎进行口腔修复治疗。[21]Lu DP. Prosthodontic management of angular cheilitis and persistent drooling: a case report. Compend Contin Educ Dent. 2007;28:572-577.http://www.ncbi.nlm.nih.gov/pubmed/18018392?tool=bestpractice.com