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已有关于在扁平苔藓 (LP) 皮损中发展为皮肤鳞状细胞癌的报告。然而，也有证据表明没有发展为该并发症的风险。[110]Sigurgeirsson B, Lindelof B. Lichen planus and malignancy: an epidemiologic study of 2071 patients and a review of the literature. Arch Dermatol. 1991;127:1684-1688.http://www.ncbi.nlm.nih.gov/pubmed/1952973?tool=bestpractice.com扁平苔藓 (LP) 皮损中皮肤鳞状细胞癌的进展风险：低质量的证据表明，LP 皮损有发展为皮肤鳞状细胞癌的风险。[110]Sigurgeirsson B, Lindelof B. Lichen planus and malignancy: an epidemiologic study of 2071 patients and a review of the literature. Arch Dermatol. 1991;127:1684-1688.http://www.ncbi.nlm.nih.gov/pubmed/1952973?tool=bestpractice.com低质量的观察性（队列）研究或者受试者＜200名且方法学存在缺陷的随机对照临床试验（RCT）。 虽然口腔 LP 对口腔恶性肿瘤的影响仍有争议，但生殖器 LP 能够增加局部鳞状细胞癌的风险。[103]Cooper SM, Wojnarowska F. Influence of treatment of erosive lichen planus of the vulva on its prognosis. Arch Dermatol. 2006;142:289-294.http://archderm.ama-assn.org/cgi/content/full/142/3/289http://www.ncbi.nlm.nih.gov/pubmed/16549703?tool=bestpractice.com[111]Gonzalez-Moles MA, Scully C, Gil-Montoya JA. Oral lichen planus: controversies surrounding malignant transformation. Oral Dis. 2008;14:229-243.http://www.ncbi.nlm.nih.gov/pubmed/18298420?tool=bestpractice.com
皮肤鳞状细胞癌
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