严重肠绞痛的婴儿（特别是那些具有特应性疾病特征或特应性疾病家族史的婴儿）应考虑暂时使用低过敏原配方奶粉，如乳清蛋白水解奶粉哭闹持续时间：有低质量的证据表明，对于减少人工喂食的肠绞痛婴儿的哭闹时间方面，蛋白水解牛奶可能比牛奶配方奶粉喂养更有效。低质量的观察性（队列）研究或者受试者＜200名且方法学存在缺陷的随机对照临床试验（RCT）。或酪蛋白水解奶粉哭闹持续时间：有低质量的证据表明，对于减少人工喂食的肠绞痛婴儿的哭闹时间方面，酪蛋白水解牛奶可能比牛奶配方奶粉喂养更有效。低质量的观察性（队列）研究或者受试者＜200名且方法学存在缺陷的随机对照临床试验（RCT）。。[23]The Norwegian Knowledge Centre for the Health Services. Treatment of infant colic. 2009. http://www.kunnskapssenteret.no (last accessed 12 July 2017).http://www.kunnskapssenteret.no/en/publications/treatment-of-infant-colic[25]Nutrition Committee, Canadian Paediatric Society. Infantile colic: is there a role for dietary interventions? Pediatr Child Health. 2011;16:47-49.http://www.cps.ca/en/documents/position/infantile-colic-dietary-interventions
治疗婴儿肠绞痛时一般应该避免使用大豆配方奶粉，这是因为大豆蛋白是婴儿期的一种重要过敏原，可能对生殖健康有长期的有害影响。[25]Nutrition Committee, Canadian Paediatric Society. Infantile colic: is there a role for dietary interventions? Pediatr Child Health. 2011;16:47-49.http://www.cps.ca/en/documents/position/infantile-colic-dietary-interventions[26]Chief Medical Officer. Advice issued on soya-based infant formulas. CMO's update 37. January 2004. http://www.dh.gov.uk/ (last accessed 12 July 2017).http://webarchive.nationalarchives.gov.uk/20130107105354/http://www.dh.gov.uk/prod_consum_dh/groups/dh_digitalassets/@dh/@en/documents/digitalasset/dh_4070176.pdf[27]Nutrition Committee, Canadian Paediatric Society. Concerns for the use of soy-based formulas in infant nutrition. Paediatr Child Health. 2009;14:109-113.http://www.cps.ca/en/documents/position/use-soy-based-formulashttp://www.ncbi.nlm.nih.gov/pubmed/19436562?tool=bestpractice.com此外，对于豆基配方奶粉中的植物雌激素含量及其对于以之作为唯一营养来源的婴儿所带来的潜在风险也存在担忧。特别是对于早产儿和患有先天性甲状腺功能减退的婴儿，应该避免使用大豆配方奶粉。
应进行一个月间期的周期性食物激发，以确认改善与饮食调整有关，而非自然消退。[25]Nutrition Committee, Canadian Paediatric Society. Infantile colic: is there a role for dietary interventions? Pediatr Child Health. 2011;16:47-49.http://www.cps.ca/en/documents/position/infantile-colic-dietary-interventions
