HSP 是主要发生于 3~15 岁儿童中的一种疾病。所有病例中约有 50% 见于 5 岁及以下人群。[3]Gedalia A. Henoch-Schonlein purpura. Curr Rheumatol Rep. 2004;6:195-202.http://www.ncbi.nlm.nih.gov/pubmed/15134598?tool=bestpractice.com 在北美洲,儿童的年发病率约为 13.5/100,000,其中白人的发病率最高,黑人最低。[1]Roberts PF, Waller TA, Brinker TM, et al. Henoch-Schonlein purpura: a review article. South Med J. 2007;100:821-824.http://www.ncbi.nlm.nih.gov/pubmed/17713309?tool=bestpractice.com[3]Gedalia A. Henoch-Schonlein purpura. Curr Rheumatol Rep. 2004;6:195-202.http://www.ncbi.nlm.nih.gov/pubmed/15134598?tool=bestpractice.com 本病在男性中更为常见,男性与女性患病率之比高达 2:1。[3]Gedalia A. Henoch-Schonlein purpura. Curr Rheumatol Rep. 2004;6:195-202.http://www.ncbi.nlm.nih.gov/pubmed/15134598?tool=bestpractice.com 在英国,亚洲人比白人更易受累,黑人的发病率最低。在英国发表的一项调查研究结果显示,HSP 的发病率高于此前的预期,为22.1/100,000。[4]Gardner-Medwin JM, Dolezalova P, Cummins C, et al. Incidence of Henoch-Schonlein purpura, Kawasaki disease, and rare vasculitides in children of different ethnic origins. Lancet. 2002;360:1197-1202.http://www.ncbi.nlm.nih.gov/pubmed/12401245?tool=bestpractice.com 由于病例通常未被报告,因此可能低估真正的患病率。HSP 可发生于 URTI 后,因此该病主要见于秋季、冬季和春季。[5]Trapani S, Micheli A, Grisolia F, et al. Henoch-Schonlein purpura in childhood: epidemiological and clinical analysis of 150 cases over a 5-year period and review of literature. Semin Arthritis Rheum. 2005;35:143-153.http://www.ncbi.nlm.nih.gov/pubmed/16325655?tool=bestpractice.com[6]Calvino MC, Llorca J, Garcia-Porrua C, et al. Henoch-Schonlein purpura in children from northwestern Spain: a 20-year epidemiologic and clinical study. Medicine (Baltimore). 2001;80:279-290.http://www.ncbi.nlm.nih.gov/pubmed/11552081?tool=bestpractice.com