淋巴水肿常发生于恶性肿瘤手术及/或放疗后,其在多种机制下与蜂窝织炎相关,包括乳腺癌及妇科癌症的淋巴结清除术,无论是否进行照射治疗。[7]Simon MS, Cody RL. Cellulitis after axillary lymph node dissection for carcinoma of the breast. Am J Med. 1992 Nov;93(5):543-8.http://www.ncbi.nlm.nih.gov/pubmed/1364813?tool=bestpractice.com[8]Dankert J, Bouma J. Recurrent acute leg cellulitis after hysterectomy with pelvic lymphadenectomy. Br J Obstet Gynaecol. 1987 Aug;94(8):788-90.http://www.ncbi.nlm.nih.gov/pubmed/3663535?tool=bestpractice.com[24]Baddour LM, Bisno AL. Recurrent cellulitis after coronary bypass surgery. JAMA. 1984 Feb 24;251(8):1049-52.http://www.ncbi.nlm.nih.gov/pubmed/6607365?tool=bestpractice.com[32]Woo PC, Lum PN, Wong SS, et al. Cellulitis complicating lymphedema. Eur J Clin Microbiol Infect Dis. 2000 Apr;19(4):294-7.http://www.ncbi.nlm.nih.gov/pubmed/10834819?tool=bestpractice.com[33]Baddour LM, Bisno AM. Non-group A beta-hemolytic streptococcal cellulitis association with venous and lymphatic compromise. Am J Med. 1985 Aug;79(2):155-9.http://www.ncbi.nlm.nih.gov/pubmed/3875287?tool=bestpractice.com 多因素分析同时发现其为蜂窝织炎的一个强预测因子。[30]Dupuy A, Benchikhi H, Roujeau JC, et al. Risk factors for erysipelas of the leg (cellulitis): case-control study. BMJ. 1999 Jun 12;318(7198):1591-4.http://www.bmj.com/content/318/7198/1591.fullhttp://www.ncbi.nlm.nih.gov/pubmed/10364117?tool=bestpractice.com
淋巴损伤可能导致局部的宿主防御功能降低,从而导致继发感染。