由于在生理学上按时间发生的皮肤老化是主要的皱纹成因,因此所有人群均会随年龄增长而形成皱纹。中度和重度面部皱纹,常在 40 岁后变得明显。[7]Ernster VL, Grady D, Miike R, et al. Facial wrinkling in men and women, by smoking status. Am J Public Health. 1995;85:78-82.http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1615259&blobtype=pdfhttp://www.ncbi.nlm.nih.gov/pubmed/7832266?tool=bestpractice.com女性较男性更易因吸烟而引起面部皱纹。[7]Ernster VL, Grady D, Miike R, et al. Facial wrinkling in men and women, by smoking status. Am J Public Health. 1995;85:78-82.http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1615259&blobtype=pdfhttp://www.ncbi.nlm.nih.gov/pubmed/7832266?tool=bestpractice.com亚洲人群的皮肤老化特征发展情况有别于欧洲人群。肤色白的人群比肤色黑或亚洲皮肤类型的人群更易于形成皱纹。[8]Tsukahara K, Fujimura T, Yoshida Y, et al. Comparison of age-related changes in wrinkling and sagging of the skin in Caucasian females and in Japanese females. J Cosmet Sci. 2004;55:351-371.http://www.ncbi.nlm.nih.gov/pubmed/15386027?tool=bestpractice.com华人女性面部起皱具有延迟性,她们似乎在 40-50 岁间快速老化。[9]Nouveau-Richard S, Yang Z, Mac-Mary S, et al. Skin ageing: a comparison between Chinese and European populations. A pilot study. J Dermatol Sci. 2005;40:187-193.http://www.ncbi.nlm.nih.gov/pubmed/16154324?tool=bestpractice.com皮肤白皙的人群(Fitzpatrick 分型法定义的 I 类至 III 类)比其他皮肤类型的人群更易受日光损害和光老化影响。[10]Fitzpatrick TB. The validity and practicality of sun-reactive skin types I through VI. Arch Dermatol. 1988;124:869-871.http://www.ncbi.nlm.nih.gov/pubmed/3377516?tool=bestpractice.com