疾病缓解:有中等质量的证据表明,在减少疾病复发方面,用糠酸莫米松进行治疗优于只利用润肤剂。[29]Veien NK, Olhom Larsen P, Thestrup-Pedersen K, et al. Long-term, intermittent treatment of chronic hand eczema with mometasone furoate. Br J Dermatol. 1999;140:882-886.http://www.ncbi.nlm.nih.gov/pubmed/10354026?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
疾病缓解:有中等质量的证据表明,在减少疾病复发方面,用糠酸莫米松进行治疗优于只利用润肤剂。[29]Veien NK, Olhom Larsen P, Thestrup-Pedersen K, et al. Long-term, intermittent treatment of chronic hand eczema with mometasone furoate. Br J Dermatol. 1999;140:882-886.http://www.ncbi.nlm.nih.gov/pubmed/10354026?tool=bestpractice.com
减少多汗:有来自小型对照研究的低质量的证据表明,离子导入和 A 型肉毒素在减少发汗和改善结果方面已彰显效果。[20]Swartling C, Naver H, Lindberg M, et al. Treatment of dyshidrotic hand dermatitis with intradermal botulinum toxin. J Am Acad Dermatol. 2002;47:667-671.http://www.ncbi.nlm.nih.gov/pubmed/12399757?tool=bestpractice.com[21]Odia S, Vocks E, Rakoski J, et al. Successful treatment of dyshidrotic hand eczema using tap water iontophoresis with pulsed direct current. Acta Derm Venereol. 1996;76:472-474.http://www.ncbi.nlm.nih.gov/pubmed/8982415?tool=bestpractice.com[22]Wollina U, Karamfilov T. Adjuvant botulinum toxin A in dyshidrotic hand eczema: a controlled prospective pilot study with left-right comparison. J Eur Acad Dermatol Venereol. 2002;16:40-42.http://www.ncbi.nlm.nih.gov/pubmed/11952288?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
减少多汗:有来自小型对照研究的低质量的证据表明,离子导入和 A 型肉毒素在减少发汗和改善结果方面已彰显效果。[20]Swartling C, Naver H, Lindberg M, et al. Treatment of dyshidrotic hand dermatitis with intradermal botulinum toxin. J Am Acad Dermatol. 2002;47:667-671.http://www.ncbi.nlm.nih.gov/pubmed/12399757?tool=bestpractice.com[21]Odia S, Vocks E, Rakoski J, et al. Successful treatment of dyshidrotic hand eczema using tap water iontophoresis with pulsed direct current. Acta Derm Venereol. 1996;76:472-474.http://www.ncbi.nlm.nih.gov/pubmed/8982415?tool=bestpractice.com[22]Wollina U, Karamfilov T. Adjuvant botulinum toxin A in dyshidrotic hand eczema: a controlled prospective pilot study with left-right comparison. J Eur Acad Dermatol Venereol. 2002;16:40-42.http://www.ncbi.nlm.nih.gov/pubmed/11952288?tool=bestpractice.com
减少疾病严重性评分:有低质量的证据表明,在减少出汗不良性皮炎疾病活动方面,局部他克莫司堪比局部糠酸莫米他松。[31]Schnopp C, Remling R, Möhrenschlager M, et al. Topical tacrolimus (FK 506) and mometasone furoate in the treatment of dyshidrotic palmar eczema: A randomized, observer-blinded trial. J Am Acad Dermatol. 2002;46:73-77.http://www.ncbi.nlm.nih.gov/pubmed/11756949?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
减少疾病严重性评分:有低质量的证据表明,在减少出汗不良性皮炎疾病活动方面,局部他克莫司堪比局部糠酸莫米他松。[31]Schnopp C, Remling R, Möhrenschlager M, et al. Topical tacrolimus (FK 506) and mometasone furoate in the treatment of dyshidrotic palmar eczema: A randomized, observer-blinded trial. J Am Acad Dermatol. 2002;46:73-77.http://www.ncbi.nlm.nih.gov/pubmed/11756949?tool=bestpractice.com
减少治疗抵抗的病例中疾病活动:有来自回顾性研究、病例系列以及临床试验的低质量的证据表明,局部补骨脂素和光化学疗法 (PUVA) 减少局部疗法难治性患者中的疾病活动。[33]Davis MD, McEvoy M, el-Azhary RA. Topical psoralen-ultraviolet A therapy for palmoplantar dermatoses: experience with 35 consecutive patients. Mayo Clin Proc. 1998;73:407-411.http://www.ncbi.nlm.nih.gov/pubmed/9581579?tool=bestpractice.com[34]Schempp CM, Müller H, Czech W, et al. Treatment of chronic palmoplantar eczema with local bath-PUVA therapy. J Am Acad Dermatol. 1997;36:733-737.http://www.ncbi.nlm.nih.gov/pubmed/9146535?tool=bestpractice.com[35]Behrens S, von Kobyletzki G, Gruss C, et al. PUVA-bath photochemotherapy (PUVA-soak therapy) of recalcitrant dermatoses of the palms and soles. Photodermatol Photoimmunol Photomed. 1999;15:47-51.http://www.ncbi.nlm.nih.gov/pubmed/10321515?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
减少治疗抵抗的病例中疾病活动:有来自回顾性研究、病例系列以及临床试验的低质量的证据表明,局部补骨脂素和光化学疗法 (PUVA) 减少局部疗法难治性患者中的疾病活动。[33]Davis MD, McEvoy M, el-Azhary RA. Topical psoralen-ultraviolet A therapy for palmoplantar dermatoses: experience with 35 consecutive patients. Mayo Clin Proc. 1998;73:407-411.http://www.ncbi.nlm.nih.gov/pubmed/9581579?tool=bestpractice.com[34]Schempp CM, Müller H, Czech W, et al. Treatment of chronic palmoplantar eczema with local bath-PUVA therapy. J Am Acad Dermatol. 1997;36:733-737.http://www.ncbi.nlm.nih.gov/pubmed/9146535?tool=bestpractice.com[35]Behrens S, von Kobyletzki G, Gruss C, et al. PUVA-bath photochemotherapy (PUVA-soak therapy) of recalcitrant dermatoses of the palms and soles. Photodermatol Photoimmunol Photomed. 1999;15:47-51.http://www.ncbi.nlm.nih.gov/pubmed/10321515?tool=bestpractice.com
减少治疗抵抗的病例中的疾病活动:有来自病例报告或系列或图表评论以及单一随机对照试验的低质量的证据表明,这些药剂可减少局部治疗难治性患者中的疾病活动。[36]Egan CA, Rallis TM, Meadows KP, et al. Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx. J Am Acad Derm. 1999;40:612-614.http://www.ncbi.nlm.nih.gov/pubmed/10188683?tool=bestpractice.com[37]Scerri L. Azathioprine in dermatological practice. An overview with special emphasis on its use in non-bullous inflammatory dermatoses. Adv Exp Med Biol. 1999;455:343-348.http://www.ncbi.nlm.nih.gov/pubmed/10599368?tool=bestpractice.com[38]Granlund H, Erkko P, Eriksson E, et al. Comparison of cyclosporine and topical betamethasone-17, 21-dipropionate in the treatment of severe chronic hand eczema. Acta Derm Venereol. 1996;76:371-376.http://www.ncbi.nlm.nih.gov/pubmed/8891011?tool=bestpractice.com[39]Pickenäcker A, Luger TA, Schwartz T. Dyshidrotic eczema treated with mycophenolate mofetil. Arch Dermatol. 1998;134:378-379.http://www.ncbi.nlm.nih.gov/pubmed/9521043?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
减少治疗抵抗的病例中的疾病活动:有来自病例报告或系列或图表评论以及单一随机对照试验的低质量的证据表明,这些药剂可减少局部治疗难治性患者中的疾病活动。[36]Egan CA, Rallis TM, Meadows KP, et al. Low-dose oral methotrexate treatment for recalcitrant palmoplantar pompholyx. J Am Acad Derm. 1999;40:612-614.http://www.ncbi.nlm.nih.gov/pubmed/10188683?tool=bestpractice.com[37]Scerri L. Azathioprine in dermatological practice. An overview with special emphasis on its use in non-bullous inflammatory dermatoses. Adv Exp Med Biol. 1999;455:343-348.http://www.ncbi.nlm.nih.gov/pubmed/10599368?tool=bestpractice.com[38]Granlund H, Erkko P, Eriksson E, et al. Comparison of cyclosporine and topical betamethasone-17, 21-dipropionate in the treatment of severe chronic hand eczema. Acta Derm Venereol. 1996;76:371-376.http://www.ncbi.nlm.nih.gov/pubmed/8891011?tool=bestpractice.com[39]Pickenäcker A, Luger TA, Schwartz T. Dyshidrotic eczema treated with mycophenolate mofetil. Arch Dermatol. 1998;134:378-379.http://www.ncbi.nlm.nih.gov/pubmed/9521043?tool=bestpractice.com