几种家族性偏头痛为常染色体显性遗传疾病,不过目前基因诊断需要转交研究实验室。[38]Marcus DA, Furman JM. Prevention of motion sickness with rizatriptan: a double-blind, placebo-controlled pilot study. Med Sci Monit. 2006 Jan;12(1):1-7.https://www.medscimonit.com/download/index/idArt/443201[39]Stewart WF, Bigal ME, Kolodner K, et al. Familial risk of migraine: variation by proband age at onset and headache severity. Neurology. 2006 Feb 14;66(3):344-8.http://www.ncbi.nlm.nih.gov/pubmed/16476932?tool=bestpractice.com[40]Terwindt GM, Ophoff RA, van Eijk R, et al. Involvement of the CACNA1A gene containing region on 19p13 in migraine with and without aura. Neurology. 2001 Apr 24;56(8):1028-32.http://www.ncbi.nlm.nih.gov/pubmed/11320173?tool=bestpractice.com[41]Pierelli F, Grieco GS, Pauri F, et al. A novel ATP1A2 mutation in a family with FHM type II. Cephalalgia. 2006 Mar;26(3):324-8.http://www.ncbi.nlm.nih.gov/pubmed/16472340?tool=bestpractice.com[42]Vanmolkot KR, Kors EE, Turk U, et al. Two de novo mutations in the Na,K-ATPase gene ATP1A2 associated with pure familial hemiplegic migraine. Eur J Hum Genet. 2006 May;14(5):555-60.http://www.nature.com/ejhg/journal/v14/n5/full/5201607a.htmlhttp://www.ncbi.nlm.nih.gov/pubmed/16538223?tool=bestpractice.com[43]Dichgans M, Freilinger T, Eckstein G, et al. Mutation in the neuronal voltage-gated sodium channel SCN1A in familial hemiplegic migraine. Lancet. 2005 Jul 30-Aug 5;366(9483):371-7.http://www.ncbi.nlm.nih.gov/pubmed/16054936?tool=bestpractice.com 尚未发现常见类型偏头痛的基因,但有人认为这是一种多基因病。[44]Kirchmann M, Thomsen LL, Olesen J. The CACNA1A and ATP1A2 genes are not involved in dominantly inherited migraine with aura. Am J Med Genet B Neuropsychiatr Genet. 2006 Apr 5;141B(3):250-6.http://www.ncbi.nlm.nih.gov/pubmed/16508934?tool=bestpractice.com[45]Gardner KL. Genetics of migraine: an update. Headache. 2006 Jun;46 Suppl 1:S19-24.http://www.ncbi.nlm.nih.gov/pubmed/16927960?tool=bestpractice.com