晕动病的抑制:有高质量的证据表明,与候选药物以及音乐和控制呼吸相比,东莨菪碱(莨菪碱)可有效抑制晕动病。[52]Yen Pik Sang FD, Billar JP, Golding JF, et al. Behavioral methods of alleviating motion sickness: effectiveness of controlled breathing and a music audiotape. J Travel Med. 2003;10:108-111.http://onlinelibrary.wiley.com/doi/10.2310/7060.2003.31768/epdfhttp://www.ncbi.nlm.nih.gov/pubmed/12650654?tool=bestpractice.com[53]Yen Pik Sang FD, Golding JF, Gresty MA. Suppression of sickness by controlled breathing during mildly nauseogenic motion. Aviat Space Environ Med. 2003;74:998-1002.http://www.ncbi.nlm.nih.gov/pubmed/14503682?tool=bestpractice.com[54]Wood CD, Graybiel A. Evaluation of 16 antimotion sickness drugs under controlled laboratory conditions. Aerospace Med. 1968;39:1341-1344.[55]Spinks AB, Wasiak J. Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database Syst Rev. 2011;(6):CD002851.http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002851.pub4/fullhttp://www.ncbi.nlm.nih.gov/pubmed/21678338?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
晕动病的抑制:有高质量的证据表明,与候选药物以及音乐和控制呼吸相比,东莨菪碱(莨菪碱)可有效抑制晕动病。[52]Yen Pik Sang FD, Billar JP, Golding JF, et al. Behavioral methods of alleviating motion sickness: effectiveness of controlled breathing and a music audiotape. J Travel Med. 2003;10:108-111.http://onlinelibrary.wiley.com/doi/10.2310/7060.2003.31768/epdfhttp://www.ncbi.nlm.nih.gov/pubmed/12650654?tool=bestpractice.com[53]Yen Pik Sang FD, Golding JF, Gresty MA. Suppression of sickness by controlled breathing during mildly nauseogenic motion. Aviat Space Environ Med. 2003;74:998-1002.http://www.ncbi.nlm.nih.gov/pubmed/14503682?tool=bestpractice.com[54]Wood CD, Graybiel A. Evaluation of 16 antimotion sickness drugs under controlled laboratory conditions. Aerospace Med. 1968;39:1341-1344.[55]Spinks AB, Wasiak J. Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database Syst Rev. 2011;(6):CD002851.http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD002851.pub4/fullhttp://www.ncbi.nlm.nih.gov/pubmed/21678338?tool=bestpractice.com
东莨菪碱(莨菪碱)血药浓度:有高质量的证据表明,鼻腔给药氢溴酸东莨菪碱(氢溴酸莨菪碱)时可取得有效的东莨菪碱血药浓度。吸收随着配方 pH 值和剂量的增加而大幅增加。[72]Ahmed S, Sileno AP, de Meireles JC, et al. Effects of pH and dose on nasal absorption of scopolamine hydrobromide in human subjects. Pharm Res. 2000;17:974-977.http://www.ncbi.nlm.nih.gov/pubmed/11028944?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
东莨菪碱(莨菪碱)血药浓度:有高质量的证据表明,鼻腔给药氢溴酸东莨菪碱(氢溴酸莨菪碱)时可取得有效的东莨菪碱血药浓度。吸收随着配方 pH 值和剂量的增加而大幅增加。[72]Ahmed S, Sileno AP, de Meireles JC, et al. Effects of pH and dose on nasal absorption of scopolamine hydrobromide in human subjects. Pharm Res. 2000;17:974-977.http://www.ncbi.nlm.nih.gov/pubmed/11028944?tool=bestpractice.com
晕动病的易患性:有中等质量证据表明,一项小型平衡秩序试验表明,吸烟者在戒掉尼古丁时,其出现晕动病的可能性略低。[43]Golding JF, Prosyanikova O, Flynn M, et al. The effects of smoking nicotine tobacco versus smoking deprivation on motion sickness. Aviat Space Environ Med. 2008;79:262.
系统评价或者受试者>200名的随机对照临床试验(RCT)。
晕动病的易患性:有中等质量证据表明,一项小型平衡秩序试验表明,吸烟者在戒掉尼古丁时,其出现晕动病的可能性略低。[43]Golding JF, Prosyanikova O, Flynn M, et al. The effects of smoking nicotine tobacco versus smoking deprivation on motion sickness. Aviat Space Environ Med. 2008;79:262.
运动挑战耐受性:有中等质量证据表明,音源性反馈训练提供的运动挑战耐受性明显高于肌注异丙嗪或安慰剂。[61]Cowings PS, Toscano WB. Autogenic-feedback training exercise is superior to promethazine for control of motion sickness symptoms. J Clin Pharmacol. 2000;40:1154-1165.http://www.ncbi.nlm.nih.gov/pubmed/11028255?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
运动挑战耐受性:有中等质量证据表明,音源性反馈训练提供的运动挑战耐受性明显高于肌注异丙嗪或安慰剂。[61]Cowings PS, Toscano WB. Autogenic-feedback training exercise is superior to promethazine for control of motion sickness symptoms. J Clin Pharmacol. 2000;40:1154-1165.http://www.ncbi.nlm.nih.gov/pubmed/11028255?tool=bestpractice.com
晕动病的抑制:有中等质量证据表明,认知行为疗法可抑制晕动病。[65]Dobie TG, May JG. Cognitive-behavioural management of motion sickness. Aviat Space Environ Med. 1994;65:C1-C2.http://www.ncbi.nlm.nih.gov/pubmed/7811217?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
晕动病的抑制:有中等质量证据表明,认知行为疗法可抑制晕动病。[65]Dobie TG, May JG. Cognitive-behavioural management of motion sickness. Aviat Space Environ Med. 1994;65:C1-C2.http://www.ncbi.nlm.nih.gov/pubmed/7811217?tool=bestpractice.com
晕动病的易患性:有中等质量证据表明,与安慰剂相比,用利扎曲坦预处理后,偏头痛眩晕患者的晕动病易患性有所降低。[68]Marcus DA, Furman JM. Prevention of motion sickness with rizatriptan: a double-blind, placebo-controlled pilot study. Med Sci Monit. 2006;12:PI1-PI7.http://www.ncbi.nlm.nih.gov/pubmed/16369474?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
晕动病的易患性:有中等质量证据表明,与安慰剂相比,用利扎曲坦预处理后,偏头痛眩晕患者的晕动病易患性有所降低。[68]Marcus DA, Furman JM. Prevention of motion sickness with rizatriptan: a double-blind, placebo-controlled pilot study. Med Sci Monit. 2006;12:PI1-PI7.http://www.ncbi.nlm.nih.gov/pubmed/16369474?tool=bestpractice.com