多个研究证实它是重要的危险因素,胎盘早剥的风险加倍。[15]Ananth CV, Smulian JC, Vintzileos AM. Incidence of placental abruption in relation to cigarette smoking and hypertensive disorders during pregnancy: a meta-analysis of observational studies. Obstet Gynecol. 1999;93:622-628.http://www.ncbi.nlm.nih.gov/pubmed/10214847?tool=bestpractice.com[17]Williams MA, Mittendorf R, Monson RR. Chronic hypertension, cigarette smoking, and abruptio placentae. Epidemiology. 1991;2:450-453.http://www.ncbi.nlm.nih.gov/pubmed/1790199?tool=bestpractice.com[19]Tikkanen M, Nuutila M, Hiilesmaa V, et al. Clinical presentation and risk factors of placental abruption. Acta Obstet Gynecol Scand. 2006;85:700-705.http://www.ncbi.nlm.nih.gov/pubmed/16752262?tool=bestpractice.com[21]Ananth CV, Savitz DA, Luther ER. Maternal cigarette smoking as a risk factor for placental abruption, placenta previa, and uterine bleeding in pregnancy. Am J Epidemiol. 1996;144:881-889.http://www.ncbi.nlm.nih.gov/pubmed/8890666?tool=bestpractice.com[22]Ananth CV, Cnattingius S. Influence of maternal smoking on placental abruption in successive pregnancies: a population-based prospective cohort study in Sweden. Am J Epidemiol. 2007;166:289-295.http://aje.oxfordjournals.org/cgi/content/full/166/3/289http://www.ncbi.nlm.nih.gov/pubmed/17548787?tool=bestpractice.com[23]Tikkanen M, Nuutila M, Hiilesmaa V, et al. Prepregnancy risk factors for placental abruption. Acta Obstet Gynecol Scand. 2006;85:40-44.http://www.ncbi.nlm.nih.gov/pubmed/16521678?tool=bestpractice.com[24]Tuthill DP, Stewart JH, Coles EC, et al. Maternal cigarette smoking and pregnancy outcome. Paediatr Perinat Epidemiol. 1999;13:245-253.http://www.ncbi.nlm.nih.gov/pubmed/10440045?tool=bestpractice.com[25]Brink AL, Odendaal HJ. Risk factors for abruptio placentae. S Afr Med J. 1987;72:250-252.http://www.ncbi.nlm.nih.gov/pubmed/3616809?tool=bestpractice.com早剥的风险与每天吸烟的数量和吸烟史的持续时间有关。[26]Raymond EG, Mills JL. Placental abruption. Maternal risk factors and associated fetal conditions. Acta Obstet Gynecol Scand. 1993;72:633-639.http://www.ncbi.nlm.nih.gov/pubmed/8259750?tool=bestpractice.com