在初始改善后症状恶化(即“二次患病”)同样提示继发性细菌感染。 典型情景是患者先出现病毒性鼻窦炎并在 5 天内改善,但 2~3 天后又恶化。[1]Lanza DC, Kennedy DW. Adult rhinosinusitis defined. Otolaryngol Head Neck Surg. 1997 Sep;117(3 Pt 2):S1-7.http://www.ncbi.nlm.nih.gov/pubmed/9334782?tool=bestpractice.com[2]Rosenfeld RM, Piccirillo JF, Chandrasekhar SS, et al. Clinical practice guideline (update): adult sinusitis. Otolaryngol Head Neck Surg. 2015 Apr;152(2 Suppl):S1-39.https://journals.sagepub.com/doi/full/10.1177/0194599815572097http://www.ncbi.nlm.nih.gov/pubmed/25832968?tool=bestpractice.com[3]Peters AT, Spector S, Hsu J, et al. Diagnosis and management of rhinosinusitis: a practice parameter update. Ann Allergy Asthma Immunol. 2014 Oct;113(4):347-85.https://www.aaaai.org/Aaaai/media/MediaLibrary/PDF%20Documents/Practice%20and%20Parameters/2014-October_Rhinosinusitis_Update.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/25256029?tool=bestpractice.com[23]Meltzer EO, Hamilos DL, Hadley JA, et al; Rhinosinusitis Initiative. Rhinosinusitis: developing guidance for clinical trials. Otolaryngol Head Neck Surg. 2006 Nov;135(5 Suppl):S31-80.http://www.ncbi.nlm.nih.gov/pubmed/17081855?tool=bestpractice.com[24]Fokkens WJ, Lund VJ, Mullol J, et al. EPOS 2012: European position paper on rhinosinusitis and nasal polyps 2012. A summary for otorhinolaryngologists. Rhinology. 2012 Mar;50(1):1-12.http://www.ncbi.nlm.nih.gov/pubmed/22469599?tool=bestpractice.com