全球异位妊娠率为 1.1%(英国)、1.49%(挪威)、1.62%(澳大利亚)。[10]Bakken IJ, Skjeldestad FE. Incidence and treatment of extrauterine pregnancies in Norway 1990-2001. Tidsskr Nor Laegeforen. 2003 Nov 6;123(21):3016-20.http://www.ncbi.nlm.nih.gov/pubmed/14618166?tool=bestpractice.com[11]Lewis G, Drife J. Why Mothers Die 2000-2002. The sixth report of the Confidential Enquiry into Maternal Deaths in the United Kingdom. London, UK: Royal College of Obstetricians and Gynaecologists; 2004. 在美国 15 岁至 44 岁的女性中,异位妊娠在全部妊娠中的发生比率变化趋势依然相对稳定。[12]Centers for Disease Control and Prevention. 2016 sexually transmitted diseases surveillance: STDs in women and infants. October 2016 [internet publication].https://www.cdc.gov/std/stats16/default.htm 1992 年,美国报道的妊娠中有 2% 为异位妊娠。[13]Centers for Disease Control and Prevention (CDC). Ectopic pregnancy - United States, 1990-1992. MMWR Morb Mortal Wkly Rep. 1995 Jan 27;44(3):46-8.http://www.cdc.gov/mmwr/preview/mmwrhtml/00035709.htmhttp://www.ncbi.nlm.nih.gov/pubmed/7823895?tool=bestpractice.com 由于现在临床治疗趋向于以门诊治疗为主,监测变得越来越不可靠,因此,自 20 世纪 90 年代以来,关于异位妊娠发生率的国家监测数据尚未更新。[13]Centers for Disease Control and Prevention (CDC). Ectopic pregnancy - United States, 1990-1992. MMWR Morb Mortal Wkly Rep. 1995 Jan 27;44(3):46-8.http://www.cdc.gov/mmwr/preview/mmwrhtml/00035709.htmhttp://www.ncbi.nlm.nih.gov/pubmed/7823895?tool=bestpractice.com[12]Centers for Disease Control and Prevention. 2016 sexually transmitted diseases surveillance: STDs in women and infants. October 2016 [internet publication].https://www.cdc.gov/std/stats16/default.htm 针对 2002-2007 年间有商业保险的美国女性的分析结果发现,异位妊娠发生率没有增加或减少的趋势。[14]Hoover KW, Tao G, Kent CK. Trends in the diagnosis and treatment of ectopic pregnancy in the United States. Obstet Gynecol. 2010 Mar;115(3):495-502.http://www.ncbi.nlm.nih.gov/pubmed/20177279?tool=bestpractice.com
在美国,异位妊娠死亡率从 1980 年至 1984 年每 100,000 例活产中 1.15 例死亡下降到 2003 年至 2007 年每 100,000 例活产中 0.50 例死亡。[15]Creanga AA, Shapiro-Mendoza CK, Bish CL, et al. Trends in ectopic pregnancy mortality in the United States: 1980-2007. Obstet Gynecol. 2011 Apr;117(4):837-43.http://www.ncbi.nlm.nih.gov/pubmed/21422853?tool=bestpractice.com