如果基底细胞癌的切缘是阳性的,则其具有很高的复发可能性及持续的局部增长率。如果不予治疗,局部破坏性增长是可能的。[41]Bogelund FS, Philipsen PA, Gniadecki R. Factors affecting the recurrence rate of Basal cell carcinoma. Acta Derm Venereol. 2007;87:330-334.http://www.ncbi.nlm.nih.gov/pubmed/17598036?tool=bestpractice.com[61]Barlow JO, Zalla MJ, Kyle A, et al. Treatment of basal cell carcinoma with curettage alone. J Am Acad Dermatol. 2006;54:1039-1045.http://www.ncbi.nlm.nih.gov/pubmed/16713459?tool=bestpractice.com[33]Smeets NW, Stavast-Kooy AJ, Krekels GA, et al. Adjuvant cytokeratin staining in Mohs micrographic surgery for basal cell carcinoma. Dermatol Surg. 2003;29:375-377.http://www.ncbi.nlm.nih.gov/pubmed/12656816?tool=bestpractice.com[44]Vidal D, Matias-Guiu X, Alomar A. Fifty-five basal cell carcinomas treated with topical imiquimod: outcome at 5-year follow-up. Arch Dermatol. 2007;143:266-268.http://www.ncbi.nlm.nih.gov/pubmed/17310012?tool=bestpractice.com[37]Bath-Hextall FJ, Perkins W, Bong J, et al. Interventions for basal cell carcinoma of the skin. Cochrane Database Syst Rev. 2007;(1):CD003412.http://www.ncbi.nlm.nih.gov/pubmed/17253489?tool=bestpractice.com[48]Bukhardt Perez MP, Ruiz-Villaverde R, Naranjo Diaz MJ, et al. Basal cell carcinoma: treatment with imiquimod. Int J Dermatol. 2007;46:539-542.http://www.ncbi.nlm.nih.gov/pubmed/17472691?tool=bestpractice.com[43]Dixon AJ. Multiple superficial basal cell carcinomata--topical imiquimod versus curette and cryotherapy. Aust Fam Physician. 2005;34:49-52.http://www.ncbi.nlm.nih.gov/pubmed/15727358?tool=bestpractice.com[37]Bath-Hextall FJ, Perkins W, Bong J, et al. Interventions for basal cell carcinoma of the skin. Cochrane Database Syst Rev. 2007;(1):CD003412.http://www.ncbi.nlm.nih.gov/pubmed/17253489?tool=bestpractice.com[62]Berlin JM, Leeman DR, Spunberg JJ, et al. Radiotherapy for rodent ulcer type of basal cell carcinoma. Dermatol Surg. 2007;33:513-515.http://www.ncbi.nlm.nih.gov/pubmed/17430392?tool=bestpractice.com[63]Hirschsteiner O, Maiwald G, Balda BR. Guess what! Diagnosis: extended ulcerating metatypical basal cell carcinoma (BCC) with soft tissue and bone destruction. Eur J Dermatol. 2000;10:315-316.http://www.ncbi.nlm.nih.gov/pubmed/10939863?tool=bestpractice.com
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