BMJ Best Practice
最后审核时间: 七月 2019
最近更新时间: 五月 2019

小结

定义

病史和查体

关键诊断因素

  • Paget 病家族史
  • 无症状

其他诊断因素

  • 累及股骨、骨盆和/或颅骨
  • 长骨或背部疼痛
  • 病理性骨折
  • 骨骼畸形(例如额部隆起、下颌前突、骨弯曲)

危险因素

  • Paget 病家族史
  • 年龄>50 岁
  • 男性(45~74 岁)
  • 感染

诊断性检查

首要检查

  • X 线平片
  • 骨扫描
  • 血清总碱性膦酸酶
  • 骨特异性碱性膦酸酶
全部具体信息

需要考虑的检查

  • CT 扫描或 MRI
  • 骨活检
全部具体信息

治疗流程

贡献者

Associate Physician

Assistant Professor of Medicine

Brigham and Women's Hospital

Department of Orthopaedics and Medicine/Rheumatology

Boston

MA

利益冲突披露
JFC has received royalties from Up To Date, Waltham, MA, for authorship on articles relating to Paget disease of bone (PDB). JFC has also received grant funding from the NIH, Rheumatology Research Foundation and Brigham and Women's Hospital for research into regulation of osteoclast function, but not specifically relating to PDB. JFC has had a manuscript published from a collaboration with Dr. Jae Shim describing a Pagetic phenotype in mice with osteoclast-specific loss of Chmp5.

Dr Julia F. Charles would like to gratefully acknowledge Dr Camilo Restrepo and Dr Javad Parvizi, previous contributors to this topic. CR and JP are authors of references cited in this topic.

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Director

Endocrine/Bone Disease Program

John Wayne Cancer Institute

Santa Monica

CA

利益冲突披露
FS declares that he has no competing interests.

Orthopaedic Surgeon

Hospital for Special Surgery

New York

NY

利益冲突披露
JL declares that he has no competing interests.

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