瘢痕缩小和消退:质量差的证据显示,瘢痕切除术后使用丝裂霉素 C 可有效改善治疗效果。[25]Talmi YP, Orenstein A, Wolf M, et al. Use of mitomycin C for treatment of keloid: a preliminary report. Otolaryngol Head Neck Surg. 2005;132:598-601.http://www.ncbi.nlm.nih.gov/pubmed/15806053?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
瘢痕缩小和消退:质量差的证据显示,瘢痕切除术后使用丝裂霉素 C 可有效改善治疗效果。[25]Talmi YP, Orenstein A, Wolf M, et al. Use of mitomycin C for treatment of keloid: a preliminary report. Otolaryngol Head Neck Surg. 2005;132:598-601.http://www.ncbi.nlm.nih.gov/pubmed/15806053?tool=bestpractice.com
瘢痕缩小和消退:质量差的证据显示,博来霉素可有效减小瘢痕大小,并可引起较高的消退率。[26]Saray Y, Güleç AT. Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study. Int J Dermatol. 2005;44:777-784.http://www.ncbi.nlm.nih.gov/pubmed/16135153?tool=bestpractice.com[27]Aggarwal H, Saxena A, Lubana PS, et al. Treatment of keloids and hypertrophic scars using bleomycin. J Cosmet Dermatol. 2008;7:43-49.http://www.ncbi.nlm.nih.gov/pubmed/18254811?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
瘢痕缩小和消退:质量差的证据显示,博来霉素可有效减小瘢痕大小,并可引起较高的消退率。[26]Saray Y, Güleç AT. Treatment of keloids and hypertrophic scars with dermojet injections of bleomycin: a preliminary study. Int J Dermatol. 2005;44:777-784.http://www.ncbi.nlm.nih.gov/pubmed/16135153?tool=bestpractice.com[27]Aggarwal H, Saxena A, Lubana PS, et al. Treatment of keloids and hypertrophic scars using bleomycin. J Cosmet Dermatol. 2008;7:43-49.http://www.ncbi.nlm.nih.gov/pubmed/18254811?tool=bestpractice.com
瘢痕缩小和消退:质量差的证据显示,5-氟尿嘧啶(可单独外用或病灶内注射),在治疗瘢痕疙瘩方面有效(当使用 5-FU 作为单药治疗时,20 名患者中的 85% 显示病情改善 > 50%)。[28]Uppal RS, Khan U, Kakar S, et al. The effects of a single dose of 5-fluorouracil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision. Plast Reconstr Surg. 2001;108:1218-1224.http://www.ncbi.nlm.nih.gov/pubmed/11604622?tool=bestpractice.com[29]Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, et al. Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study. J Am Acad Dermatol. 2005;52:474-479.http://www.ncbi.nlm.nih.gov/pubmed/15761426?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
瘢痕缩小和消退:质量差的证据显示,5-氟尿嘧啶(可单独外用或病灶内注射),在治疗瘢痕疙瘩方面有效(当使用 5-FU 作为单药治疗时,20 名患者中的 85% 显示病情改善 > 50%)。[28]Uppal RS, Khan U, Kakar S, et al. The effects of a single dose of 5-fluorouracil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision. Plast Reconstr Surg. 2001;108:1218-1224.http://www.ncbi.nlm.nih.gov/pubmed/11604622?tool=bestpractice.com[29]Kontochristopoulos G, Stefanaki C, Panagiotopoulos A, et al. Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study. J Am Acad Dermatol. 2005;52:474-479.http://www.ncbi.nlm.nih.gov/pubmed/15761426?tool=bestpractice.com