伊托必利
多巴胺和乙酰胆碱酯酶抑制剂可加速糖尿病胃轻瘫患者的胃排空。这项临床试验正在北美进行。[81]Abell TL, Bernstein RK, Cutts T, et al. Treatment of gastroparesis: a multidisciplinary clinical review. Neurogastroenterol Motil. 2006;18:263-283.http://www.ncbi.nlm.nih.gov/pubmed/16553582?tool=bestpractice.com
米坦西那
在临床试验中，一种口服胃动素受体激动剂显示其可改善糖尿病胃轻瘫患者的胃排空及症状。[94]McCallum RW, Cynshi O; US Investigative Team. Efficacy of mitemcinal, a motilin agonist, on gastrointestinal symptoms in patients with symptoms suggesting diabetic gastropathy: a randomized, multi-center, placebo-controlled trial. Aliment Pharmacol Ther. 2007;26:107-116.http://www.ncbi.nlm.nih.gov/pubmed/17555427?tool=bestpractice.com
5-羟色胺受体4激动剂
伦扎必利和莫沙必利是5-羟色胺受体4激动剂，目前正在进行临床试验来评估其治疗胃轻瘫的疗效。[95]Mackie AD, Ferrington C, Cowan S, et al. The effects of renzapride, a novel prokinetic agent, in diabetic gastroparesis. Aliment Pharmacol Ther. 1991;5:135-142.http://www.ncbi.nlm.nih.gov/pubmed/1888816?tool=bestpractice.com[96]Asakawa H, Hayashi I, Fukui T, et al. Effect of mosapride on glycemic control and gastric emptying in type 2 diabetes mellitus patients with gastropathy. Diabetes Res Clin Pract. 2003;61:175-182.http://www.ncbi.nlm.nih.gov/pubmed/12965107?tool=bestpractice.com[97]He J, Wang Y, Ouyang X. Mosapride in treatment of diabetic gastroparesis: a meta-analysis. Chin J Gastroenterol. 2011;16:94-98.
阿考替胺
一种近期被评估用于治疗胃轻瘫患者的胆碱酯酶抑制剂。[98]Seto K, Sasaki T, Katsunuma K, et al. Acotiamide hydrochloride (Z-338), a novel prokinetic agent, restores delayed gastric emptying and feeding inhibition induced by restraint stress in rats. Neurogastroenterol Motil. 2008;20:1051-1059.http://www.ncbi.nlm.nih.gov/pubmed/18482254?tool=bestpractice.com
胃饥饿素激动剂
EX-1314、BIM-28131和TZP-101是近期在临床试验中被评估用于治疗胃轻瘫患者的试验药物。[99]Dornonville de la Cour C, Lindström E, Norlén P, et al. Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells. Regul Pept. 2004;120:23-32.http://www.ncbi.nlm.nih.gov/pubmed/15177917?tool=bestpractice.com需要进一步的研究。[100]Sallam HS, Chen JD. The prokinetic face of ghrelin. Int J Pept. 2010;493614:1-11.http://www.hindawi.com/journals/ijpep/2010/493614/http://www.ncbi.nlm.nih.gov/pubmed/20721347?tool=bestpractice.com
