在美国及其他西方人群,每 1000 个活产儿中发病 2 到 4 例。亚洲和非洲较为少见。[13]To T, Wajja A, Wales PW, et al. Population demographic indicators associated with incidence of pyloric stenosis. Arch Pediatr Adolesc Med. 2005;159:520-525.http://archpedi.ama-assn.org/cgi/content/full/159/6/520http://www.ncbi.nlm.nih.gov/pubmed/15939849?tool=bestpractice.com[14]Applegate MS, Druschel CM. The epidemiology of infantile hypertrophic pyloric stenosis in New York state, 1983 to 1990. Arch Pediatr Adolesc Med. 1995;149:1123-1129.http://www.ncbi.nlm.nih.gov/pubmed/7550816?tool=bestpractice.com[15]Schechter R, Torfs CP, Bateson TF. The epidemiology of infantile hypertrophic pyloric stenosis. Paediatr Perinat Epidemiol. 1997;11:407-427.http://www.ncbi.nlm.nih.gov/pubmed/9373863?tool=bestpractice.com男婴患病率是女婴的 4 倍左右。[16]Rasmussen L, Green A, Hansen LP. The epidemiology of infantile hypertrophic pyloric stenosis in a Danish population, 1950-84. Int J Epidemiol. 1989;18:413-417.http://www.ncbi.nlm.nih.gov/pubmed/2767855?tool=bestpractice.com该病与非孟德尔家族模式相关。[15]Schechter R, Torfs CP, Bateson TF. The epidemiology of infantile hypertrophic pyloric stenosis. Paediatr Perinat Epidemiol. 1997;11:407-427.http://www.ncbi.nlm.nih.gov/pubmed/9373863?tool=bestpractice.com与父亲患有幽门狭窄相比,母亲患有幽门狭窄更可能生育出患有该病的婴儿;但是缺乏足够的数据,难以评估母体的影响。头胎婴儿可能出现幽门狭窄的几率是二胎婴儿的两倍。[15]Schechter R, Torfs CP, Bateson TF. The epidemiology of infantile hypertrophic pyloric stenosis. Paediatr Perinat Epidemiol. 1997;11:407-427.http://www.ncbi.nlm.nih.gov/pubmed/9373863?tool=bestpractice.com[16]Rasmussen L, Green A, Hansen LP. The epidemiology of infantile hypertrophic pyloric stenosis in a Danish population, 1950-84. Int J Epidemiol. 1989;18:413-417.http://www.ncbi.nlm.nih.gov/pubmed/2767855?tool=bestpractice.com[17]Still G. Place in family as a factor in disease. Lancet. 1927;ii:795-853.该病在早产儿中较为少见,[18]Zhang AL, Cass DT, Dubois RS, et al. Infantile hypertrophic pyloric stenosis: a clinical review from a general hospital. J Paediatr Child Health. 1993;29:372-378.http://www.ncbi.nlm.nih.gov/pubmed/8240866?tool=bestpractice.com在配方奶喂养的婴儿中更常见。[19]Habbick BF, Khanna C, To T. Infantile hypertrophic pyloric stenosis: a study of feeding practices and other possible causes. CMAJ. 1989;140:401-404.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1268663/pdf/cmaj00185-0055.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/2914261?tool=bestpractice.com