淋巴结阳性胆管癌是预后不良的指标。伴有无法切除的转移的病例预后较差。常见的早期转移模式是先局部淋巴结再在肝脏中远端部位。
但行手术切除的5年生存率为20%-43%。[39]Yeh CN, Jan YY, Yeh TS, et al. Hepatic resection of the intraductal papillary type of peripheral cholangiocarcinoma. Ann Surg Oncol. 2004;11:606-611.http://www.ncbi.nlm.nih.gov/pubmed/15172934?tool=bestpractice.com[40]Nakagohri T, Asano T, Kinoshita H, et al. Aggressive surgical resection for hilar-invasive and peripheral intrahepatic cholangiocarcinoma. World J Surg. 2003;27:289-293.http://www.ncbi.nlm.nih.gov/pubmed/12607053?tool=bestpractice.com[41]Isaji S, Kawarada Y, Taoka H, et al. Clinicopathological features and outcome of hepatic resection for intrahepatic cholangiocarcinoma in Japan. J Hepatobiliary Pancreat Surg. 1999;6:108-116.http://www.ncbi.nlm.nih.gov/pubmed/10398896?tool=bestpractice.com[42]Berdah SV, Delpero JR, Garcia S, et al. A western surgical experience of peripheral cholangiocarcinoma. Br J Surg. 1996;83:1517-1521.http://www.ncbi.nlm.nih.gov/pubmed/9014664?tool=bestpractice.com手术切除结合化疗的5年生存率为26%。单独化疗的生存率小于15%。[65]Furuse J, Okusaka T, Funakoshi A, et al. Early phase II study of uracil-tegafur plus doxorubicin in patients with unresectable advanced biliary tract cancer. Jpn J Clin Oncol. 2006;36:552-556.http://www.ncbi.nlm.nih.gov/pubmed/16887837?tool=bestpractice.com对肝移植来说,术后2年的复发率为51%。[66]Meyer CG, Penn I, James L. Liver transplantation for cholangiocarcinoma results in 207 patients. Transplantation. 2000;69:1633-1637.http://www.ncbi.nlm.nih.gov/pubmed/10836374?tool=bestpractice.com