其基础病因是肌腱通过其支持带输送鞘时出现狭窄性腱鞘炎。[1]Burman M. Stenosing tendovaginitis of the dorsal and volar compartments of the wrist. AMA Arch Surg. 1952;65:752-762.http://www.ncbi.nlm.nih.gov/pubmed/12984978?tool=bestpractice.com[3]Patel MR, Bassini L. Trigger fingers and thumb: when to splint, inject, or operate. J Hand Surg Am. 1992;17:110-113.http://www.ncbi.nlm.nih.gov/pubmed/1538090?tool=bestpractice.com[5]Harvey FJ, Harvey PM, Horsley MW. De Quervain's disease: surgical or nonsurgical treatment. J Hand Surg Am. 1990;15:83-87.http://www.ncbi.nlm.nih.gov/pubmed/2299173?tool=bestpractice.com[2]Lipscomb PR. Tenosynovitis of the hand and the wrist: carpal tunnel syndrome, de Quervain's disease, trigger digit. Clin Orthop. 1959;13:164-180.[16]Sampson SP, Badalamente MA, Hurst LC, et al. Pathobiology of the human A1 pulley in trigger finger. J Hand Surg Am. 1991;16:714-721.http://www.ncbi.nlm.nih.gov/pubmed/1880372?tool=bestpractice.com支持带输送鞘是一条纤维-骨质鞘管,作为滑车系统使肌腱的拉力矢量重新定位朝向手和手指。通过此鞘管的反复剪切应力刺激发炎、增生且伴支持带输送鞘纤维化的肌腱及其滑膜内层(肌腱滑膜)。随着时间的推移,该鞘管越来越窄,直至阻碍肌腱顺畅滑动。[17]Keon-Cohen B. De Quervain's disease. J Bone Joint Surg Br. 1951;33-B:96-99.http://www.bjj.boneandjoint.org.uk/content/33-B/1/96.full.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/14814168?tool=bestpractice.com[18]Piver JD, Raney RB. De Quervain's tendovaginitis. Am J Surg. 1952;83:691-694.http://www.ncbi.nlm.nih.gov/pubmed/14914998?tool=bestpractice.com