估计罹患乳腺癌风险较高的患者比例约为 4% 并局限于乳房活组织检查提示有异型性的患者。[17]Dupont WD, Page DL. Risk factors for breast cancer in women with proliferative breast disease. N Engl J Med. 1985;312:146-151.http://www.ncbi.nlm.nih.gov/pubmed/3965932?tool=bestpractice.com[29]Hartmann LC, Sellers TA, Frost MH, et al. Benign breast disease and the risk of breast cancer. N Engl J Med. 2005;353:229-237.http://www.nejm.org/doi/full/10.1056/NEJMoa044383#t=articlehttp://www.ncbi.nlm.nih.gov/pubmed/16034008?tool=bestpractice.com 病理评估提示有异型性证据的患者必须告知其风险降低策略。 乳腺癌患者必须接受适当治疗。
原发浸润性乳腺癌
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