PVFM在普通人群中的发病率和发生率还没有具体数据。 在这些为了评估呼吸困难而转诊的患者中发现PVFM的发病率为2.8%。[18]Kenn K, Willer G, Bizer C, et al. Prevalence of vocal cord dysfunction in patients with dyspnea: first prospective clinical study. Am J Respir Crit Care Med. 1997;155:A965. 在大量文献综述中,报告患有声带反常运动功能障碍的患者中,70-74%为成人,26%为儿童,年龄从0.01岁到82岁,女性和男性的比例从2:1到3.2:1。[19]Morris MJ, Allan PF, Perkins PJ. Vocal cord dysfunction: etiologies and treatment. Clin Pulm Med. 2006;13:73-86.[20]Brugman S. The many faces of vocal cord dysfunction: what 36 years of literature tells us. Am J Respir Crit Care Med. 2003;167:A588. 几个研究描述了PVFM在子群体中的发病率。 根据记录,14-56%的病例中该疾病与哮喘共存[21]Newman KB, Dubester SN. Vocal cord dysfunction: masquerader of asthma. Semin Respir Crit Care Med. 1994;15:161.[22]Gavin LA, Wamboldt M, Brugman S, et al. Psychological and family characteristics of adolescents with vocal cord dysfunction. J Asthma. 1998;35:409-417.http://www.ncbi.nlm.nih.gov/pubmed/9734348?tool=bestpractice.com 在10%的病例中有呼吸困难。 通常,女性更易得该疾病,[18]Kenn K, Willer G, Bizer C, et al. Prevalence of vocal cord dysfunction in patients with dyspnea: first prospective clinical study. Am J Respir Crit Care Med. 1997;155:A965.[20]Brugman S. The many faces of vocal cord dysfunction: what 36 years of literature tells us. Am J Respir Crit Care Med. 2003;167:A588.[21]Newman KB, Dubester SN. Vocal cord dysfunction: masquerader of asthma. Semin Respir Crit Care Med. 1994;15:161.[23]Newman KB, Mason UG 3rd, Schmaling KB. Clinical features of vocal cord dysfunction. Am J Respir Crit Care Med. 1995;152:1382-1386.http://www.ncbi.nlm.nih.gov/pubmed/7551399?tool=bestpractice.com[24]Hicks M, Brugman SM, Katial R. Vocal cord dysfunction/paradoxical vocal fold motion. Prim Care. 2008;35:81-103.http://www.ncbi.nlm.nih.gov/pubmed/18206719?tool=bestpractice.com[25]Kenn K. Vocal cord dysfunction: what do we really know? A review [in German]. Pneumologie. 2007;61:431-439.http://www.ncbi.nlm.nih.gov/pubmed/17447211?tool=bestpractice.com[26]Parker JM, Guerrero ML. Airway function in women: bronchial hyperresponsiveness, cough, and vocal cord dysfunction. Clin Chest Med. 2004;25:321-330.http://www.ncbi.nlm.nih.gov/pubmed/15099892?tool=bestpractice.com 在关于 PVFM 患者的回顾性研究中,女性和男性的比率为 4:1。[27]Altman KW, Mirza N, Ruiz C, et al. Paradoxical vocal fold motion: presentation and treatment options. J Voice. 2000;14:99-103.http://www.ncbi.nlm.nih.gov/pubmed/10764121?tool=bestpractice.com 在运动引发哮喘症状的成人组中,PVFM阳性已经被报告高达15%。[28]Morris MJ, Deal LE, Bean DR, et al. Vocal cord dysfunction in patients with exertional dyspnea. Chest. 1999;116:1676-1682.http://journal.publications.chestnet.org/article.aspx?articleid=1078336http://www.ncbi.nlm.nih.gov/pubmed/10593794?tool=bestpractice.com