应定期对所有患者的管理进行检查回顾。内容应包括:
应建议患者在疾病期间不要中断胰岛素的应用并早期寻求专家建议。2 型糖尿病患者由钠-葡萄糖共转运蛋白 2 (SGLT-2) 抑制剂所致 DKA 的诱因通常为遗漏注射胰岛素或剂量显著减少、严重急性疾病、脱水、剧烈运动、手术、低碳水化合物饮食或大量饮酒。预防 DKA 的策略应包括,当存在诱因时暂停 SGLT-2 抑制剂、并避免遗漏注射胰岛素和大剂量减少胰岛素注射。[37]Henry RR, Dandona P, Pettus J, et al. Dapagliflozin in patients with type 1 diabetes: A post hoc analysis of the effect of insulin dose adjustments on 24-hour continuously monitored mean glucose and fasting β-hydroxybutyrate levels in a phase IIa pilot study. Diabetes Obes Metab. 2017 Jun;19(6):814-821.http://www.ncbi.nlm.nih.gov/pubmed/28098426?tool=bestpractice.com[38]Goldenberg RM, Berard LD, Cheng AY, et al. SGLT2 inhibitor-associated diabetic ketoacidosis: clinical review and recommendations for prevention and diagnosis. Clin Ther. 2016 Dec;38(12):2654-2664.e1.http://www.ncbi.nlm.nih.gov/pubmed/28003053?tool=bestpractice.com
患者(或家属和照护者)要能够准确地检测和记录血糖值、胰岛素用量、体温、呼吸频率和脉搏。当血糖值高于 16.7 mmol/L (300 mg/dL) 时,要检测血酮体(β-羟丁酸),如果患者的血酮体值偏高则需要去医院就诊以进一步评估。血糖监测频率取决于患者的临床情况:对于糖尿病控制不佳的患者 (HbA1c>53 mmol/mol [>7.0%]),建议在每餐前以及睡前均要检测血糖。[1]Kitabchi AE, Umpierrez GE, Miles JM, et al. Hyperglycemic crises in adult patients with diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2009;32:1335-1343.http://care.diabetesjournals.org/content/32/7/1335.fullhttp://www.ncbi.nlm.nih.gov/pubmed/19564476?tool=bestpractice.com[85]Scottish Intercollegiate Guidelines Network (SIGN). Management of diabetes: a national clinical guideline. November 2017.http://www.sign.ac.uk/assets/sign116.pdf