检查 活检不经常用于诊断生殖器疣，因为诊断通常是基于临床表现的。[3]Wiley DJ, Douglas J, Beutner K, et al. External genital warts: diagnosis, treatment, and prevention. Clin Infect Dis. 2002 Oct 15;35(Suppl 2):S210-24.https://academic.oup.com/cid/article/35/Supplement_2/S210/316436http://www.ncbi.nlm.nih.gov/pubmed/12353208?tool=bestpractice.com
但是，如果生殖器疣硬化，固着到基底结构，出血、溃疡或色素沉着，或经治疗仍恶化，则需要进行活检。[6]Beutner KR, Reitano MV, Richwald GA, et al. External genital warts: report of the American Medical Association consensus conference. Clin Infect Dis. 1998 Oct;27(4):796-806.http://www.ncbi.nlm.nih.gov/pubmed/9798036?tool=bestpractice.com[30]Workowski KA, Bolan GA; Centers for Disease Control and Prevention. Sexually transmitted diseases treatment guidelines, 2015. MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1-137. [Erratum in: MMWR Recomm Rep. 2015 Aug 28;64(33):924.]https://www.cdc.gov/mmwr/preview/mmwrhtml/rr6403a1.htmhttp://www.ncbi.nlm.nih.gov/pubmed/26042815?tool=bestpractice.com[39]Beutner KR, Wiley DJ, Douglas JM, et al. Genital warts and their treatment. Clin Infect Dis. 1999 Jan;28 Suppl 1:S37-56.http://www.ncbi.nlm.nih.gov/pubmed/10028109?tool=bestpractice.com 此外，在生殖器疣活检样本中可检测到有丝分裂象。[5]Kirnbauer R, Lenz P, Okun MM. Human papillomavirus. In: Bolognia JL, Jorizzo JL, Rapini RP, eds. Dermatology Vol 1. London: Mosby; 2003:1217-33.
如果活检结果与发育异常或癌变相符，则表示需转诊至专科医生进行治疗。[39]Beutner KR, Wiley DJ, Douglas JM, et al. Genital warts and their treatment. Clin Infect Dis. 1999 Jan;28 Suppl 1:S37-56.http://www.ncbi.nlm.nih.gov/pubmed/10028109?tool=bestpractice.com
