中枢性甲状腺功能减退症的发病率很低,约为 0.0006% 到 0.006%。[1]Mulder JE. Thyroid disease in women. Med Clin North Am. 1998;82:103.http://www.ncbi.nlm.nih.gov/pubmed/9457153?tool=bestpractice.com[2]Roberts CG, Ladenson PW. Hypothyroidism. Lancet. 2004;363:793-803.http://www.ncbi.nlm.nih.gov/pubmed/15016491?tool=bestpractice.com垂体腺瘤是中枢性甲状腺机能减退的最常见病因。有分泌功能的腺瘤(催乳素瘤)是最常见的垂体腺瘤 (58%),其次为生长激素瘤 (23%) 以及无分泌功能的腺瘤 (10%)。[3]Zarnegar R, Brunaud L, Clark OH. Multiple endocrine neoplasia type I. Curr Treat Options Oncol. 2002;3:335-348.http://www.ncbi.nlm.nih.gov/pubmed/12074770?tool=bestpractice.com催乳素瘤在 20 到 50 岁的女性中最常见。[4]Mindermann T, Wilson CB. Age-related and gender-related occurrence of pituitary adenomas. Clin Endocrinol. 1994;41:359-364.http://www.ncbi.nlm.nih.gov/pubmed/7893282?tool=bestpractice.com生长激素瘤和无分泌功能的腺瘤在男性中更常见。[4]Mindermann T, Wilson CB. Age-related and gender-related occurrence of pituitary adenomas. Clin Endocrinol. 1994;41:359-364.http://www.ncbi.nlm.nih.gov/pubmed/7893282?tool=bestpractice.com