建议使用遮光剂，因为日光暴露可能激活单纯疱疹病毒（HSV）进而激发EM。 应避免辐射和紫外线照射。 在频繁或严重的复发病例中，即使没有发现HSV皮损，HSV滴度能够提示疾病的复发。 每日口服伐昔洛韦有利于防止复发。 因为出疹迅速，伐昔洛韦不能及时阻止高敏反应的发生。 在极少数的药物相关性疾病中，需严格避免相关药物以防止复发。[2]Sokumbi O, Wetter DA. Clinical features, diagnosis, and treatment of erythema multiforme: a review for the practicing dermatologist. Int J Dermatol. 2012;51:889-902.http://onlinelibrary.wiley.com/doi/10.1111/j.1365-4632.2011.05348.x/fullhttp://www.ncbi.nlm.nih.gov/pubmed/22788803?tool=bestpractice.com[3]French LE, Prins C. Erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis. In: Bolognia JL, Jorizzo JL, Rapini RP, eds. Dermatology. 2nd ed. London, UK: Mosby-Elsevier; 2008:287-300.[4]Bastuji-Garin S, Rzany B, Stern RS, et al. Clinical classification of cases of toxic epidermal necrolysis, Stevens-Johnson syndrome, and erythema multiforme. Arch Dermatol. 1993;129:92-6.http://www.ncbi.nlm.nih.gov/pubmed/8420497?tool=bestpractice.com[5]Assier H, Bastuji-Garin S, Revuz J, et al. Erythema multiforme with mucous membrane involvement and Stevens-Johnson syndrome are clinically different disorders with distinct causes. Arch Dermatol. 1995;131:539-543.http://www.ncbi.nlm.nih.gov/pubmed/7741539?tool=bestpractice.com[9]Auquier-Dunant A, Mockenhaupt M, Maldi L, et al. Correlations between clinical patterns and causes of erythema multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis: results of an international prospective study. Arch Dermatol. 2002;138:1019-1024.http://www.ncbi.nlm.nih.gov/pubmed/12164739?tool=bestpractice.com
