次级预防包括对确诊病例的及时反应。检测的新模式显示,通过培养、直接荧光抗体检测以及血清学检测的诊断有所下降,而通过尿抗原检测的诊断则大幅提升。这限制了非嗜肺军团菌血清型 1 疾病的检测,并对疫情的检测和控制带来了不利影响。[45]Benin AL, Benson RF, Besser RE. Trends in legionnaires disease, 1980-1998: declining mortality and new patterns of diagnosis. Clin Infect Dis. 2002;35:1039-1046.http://www.ncbi.nlm.nih.gov/pubmed/12384836?tool=bestpractice.com应提醒有关当局,以便在必要时进行检查。[31]European Centre for Disease Prevention and Control. European Legionnaires’ Disease Surveillance Network (ELDSNet): operating procedures. January 2012. http://ecdc.europa.eu (last accessed 5 September 2017).http://ecdc.europa.eu/en/publications/Publications/1202-TED-ELDSNet-operating-procedures.pdf