预期寿命
与年龄和性别匹配的人群相比,垂体功能减退患者的死亡率高 1.8 倍。[3]Rosén T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 1990 Aug 4;336(8710):285-8.http://www.ncbi.nlm.nih.gov/pubmed/1973979?tool=bestpractice.com 与正常人群相比,垂体功能减退患者的心脑血管疾病死亡专率更高。[4]Nilsson B, Gustavasson-Kadaka E, Bengtsson BA, et al. Pituitary adenomas in Sweden between 1958 and 1991: incidence, survival and mortality. J Clin Endocrinol Metab. 2000 Apr;85(4):1420-5.http://www.ncbi.nlm.nih.gov/pubmed/10770176?tool=bestpractice.com 生长激素缺乏症可能是导致心血管疾病死亡率增加的潜在原因,因为它与导致动脉粥样硬化的血脂水平和体脂增加有关,这些都与血管疾病的发病率有关。[3]Rosén T, Bengtsson BA. Premature mortality due to cardiovascular disease in hypopituitarism. Lancet. 1990 Aug 4;336(8710):285-8.http://www.ncbi.nlm.nih.gov/pubmed/1973979?tool=bestpractice.com[67]Cook DM, Yuen KC, Biller BM, et al. American Association of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in growth hormone-deficient adults and transition patients: 2009 update. Endocr Pract. 2009 Sep-Oct;15 Suppl 2:1-29.http://www.ncbi.nlm.nih.gov/pubmed/20228036?tool=bestpractice.com 但是,有可能存在多种病因导致这些患者的死亡率过高。[69]Bates AS, Van't Hoff W, Jones PJ, et al. The effect of hypopituitarism on life expectancy. J Clin Endocrinol Metab. 1996 Mar;81(3):1169-72.http://www.ncbi.nlm.nih.gov/pubmed/8772595?tool=bestpractice.com 一项研究发现,确诊时的年龄、女性性别以及颅咽管瘤均是导致死亡率过高的显著独立危险因素。[70]Tomlinson JW, Holden N, Hills RK, et al. Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet. 2001 Feb 10;357(9254):425-31.http://www.ncbi.nlm.nih.gov/pubmed/11273062?tool=bestpractice.com