高龄产妇[12]Cleary-Goldman J, Malone FD, Vidaver J, et al; FASTER Consortium. Impact of maternal age on obstetric outcome. Obstet Gynecol. 2005;105:983-990.http://www.ncbi.nlm.nih.gov/pubmed/15863534?tool=bestpractice.com 多胎妊娠[13]Ananth CV, Demissie K, Smulian JC, et al. Placenta previa in singleton and twin births in the United States, 1989 through 1998: a comparison of risk factor profiles and associated conditions. Am J Obstet Gynecol. 2003;188:275-281.http://www.ncbi.nlm.nih.gov/pubmed/12548229?tool=bestpractice.com 吸烟[14]Mortensen JT, Thulstrup AM, Larsen H, et al. Smoking, sex of the offspring, and risk of placental abruption, placenta previa, and preeclampsia: a population-based cohort study. Acta Obstet Gynecol Scand. 2001;80:894-898.http://www.ncbi.nlm.nih.gov/pubmed/11580733?tool=bestpractice.com 可增加前置胎盘 (PP) 的风险,但机制并不明确。除了之前存在子宫瘢痕这个危险因素外,[6]Getahun D, Oyelese Y, Salihu HM, et al. Previous cesarean delivery and risks of placenta previa and placental abruption. Obstet Gynecol. 2006;107:771-778.http://www.ncbi.nlm.nih.gov/pubmed/16582111?tool=bestpractice.com 很可能有多个因素共同导致了本病的发生。