二代唑类抗真菌药
伏立康唑对申克孢子丝菌的体外活性差,但根据报告,对 2 例淋巴皮肤和骨关节孢子丝菌病患者有效。[46]Hata M, Tatsuno K, Suzuki Y, et al. Successful treatment of sporotrichosis with voriconazole. 17th Congress of International Society for Human and Animal Mycology (ISHAM). Tokyo, Japan. 2009. Abstract #PP-03-12.泊沙康唑对申克孢子丝菌有良好的体外活性,也已经证明对孢子丝菌病小鼠模型有体内活性,[47]Fernández-Silva F, Capilla J, Mayayo E, et al. Efficacy of posaconazole in murine experimental sporotrichosis. Antimicrob Agents Chemother. 2012;56:2273-2277.http://www.ncbi.nlm.nih.gov/pubmed/22330929?tool=bestpractice.com但没有体内的临床数据支持其用于孢子丝菌病患者。[31]Kauffman CA, Bustamante B, Chapman SW, et al. Clinical practice guidelines for the management of sporotrichosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis. 2007;45:1255-1265.http://cid.oxfordjournals.org/content/45/10/1255.full.pdf+htmlhttp://www.ncbi.nlm.nih.gov/pubmed/17968818?tool=bestpractice.com
棘白菌素类药物
棘白菌素类药物(例如卡泊芬净、云母真菌精、阿尼芬净)对申克孢子丝菌有中度体外活性,但没有体内数据支持其用于孢子丝菌病患者。[48]Espinel-Ingroff A. Comparison of In vitro activities of the new triazole SCH56592 and the echinocandins MK-0991 (L-743,872) and LY303366 against opportunistic filamentous and dimorphic fungi and yeasts. J Clin Microbiol. 1998;36:2950-2956.http://www.ncbi.nlm.nih.gov/pubmed/9738049?tool=bestpractice.com