临床痊愈:来自多项开放性非随机试验(每项试验的患者人数都较少)的中等质量证据表明,伊曲康唑有效,可使 >90% 的淋巴皮肤型孢子丝菌病患者临床痊愈。[32]Sharkey-Mathis PK, Kauffman CA, Graybill JR, et al. Treatment of sporotrichosis with itraconazole. NIAID Mycoses Study Group. Am J Med. 1993;95:279-285.http://www.ncbi.nlm.nih.gov/pubmed/8396321?tool=bestpractice.com[33]Restrepo A, Robledo J, Gómez I, et al. Itraconazole therapy in lymphangitic and cutaneous sporotrichosis. Arch Dermatol. 1986;122:413-417.http://www.ncbi.nlm.nih.gov/pubmed/3006602?tool=bestpractice.com[34]Conti Díaz IA, Civila E, Gezuele E, et al. Treatment of human cutaneous sporotrichosis with itraconazole. Mycoses. 1992;35:153-156.http://www.ncbi.nlm.nih.gov/pubmed/1335550?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
临床痊愈:来自多项开放性非随机试验(每项试验的患者人数都较少)的中等质量证据表明,伊曲康唑有效,可使 >90% 的淋巴皮肤型孢子丝菌病患者临床痊愈。[32]Sharkey-Mathis PK, Kauffman CA, Graybill JR, et al. Treatment of sporotrichosis with itraconazole. NIAID Mycoses Study Group. Am J Med. 1993;95:279-285.http://www.ncbi.nlm.nih.gov/pubmed/8396321?tool=bestpractice.com[33]Restrepo A, Robledo J, Gómez I, et al. Itraconazole therapy in lymphangitic and cutaneous sporotrichosis. Arch Dermatol. 1986;122:413-417.http://www.ncbi.nlm.nih.gov/pubmed/3006602?tool=bestpractice.com[34]Conti Díaz IA, Civila E, Gezuele E, et al. Treatment of human cutaneous sporotrichosis with itraconazole. Mycoses. 1992;35:153-156.http://www.ncbi.nlm.nih.gov/pubmed/1335550?tool=bestpractice.com
临床痊愈:来自一项随机和多项开放性非随机临床试验(每项试验的患者人数都较少)的中等质量证据表明,碘酸钾饱和溶液可使 >80% 的淋巴皮肤型孢子丝菌病患者临床痊愈。[9]da Rosa AC, Scroferneker ML, Vettorato R, et al. Epidemiology of sporotrichosis: a study of 304 cases in Brazil. J Am Acad Dermatol. 2005;52:451-459.http://www.ncbi.nlm.nih.gov/pubmed/15761423?tool=bestpractice.com[36]Cabezas C, Bustamante B, Holgado W, et al. Treatment of cutaneous sporotrichosis with one daily dose of potassium iodide. Pediatr Infect Dis J. 1996;15:352-354.http://www.ncbi.nlm.nih.gov/pubmed/8866807?tool=bestpractice.com[37]Itoh M, Okamoto S, Kariya H. Survey of 200 cases of sporotrichosis. Dermatologica. 1986;172:209-213.http://www.ncbi.nlm.nih.gov/pubmed/3709907?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
临床痊愈:来自一项随机和多项开放性非随机临床试验(每项试验的患者人数都较少)的中等质量证据表明,碘酸钾饱和溶液可使 >80% 的淋巴皮肤型孢子丝菌病患者临床痊愈。[9]da Rosa AC, Scroferneker ML, Vettorato R, et al. Epidemiology of sporotrichosis: a study of 304 cases in Brazil. J Am Acad Dermatol. 2005;52:451-459.http://www.ncbi.nlm.nih.gov/pubmed/15761423?tool=bestpractice.com[36]Cabezas C, Bustamante B, Holgado W, et al. Treatment of cutaneous sporotrichosis with one daily dose of potassium iodide. Pediatr Infect Dis J. 1996;15:352-354.http://www.ncbi.nlm.nih.gov/pubmed/8866807?tool=bestpractice.com[37]Itoh M, Okamoto S, Kariya H. Survey of 200 cases of sporotrichosis. Dermatologica. 1986;172:209-213.http://www.ncbi.nlm.nih.gov/pubmed/3709907?tool=bestpractice.com
临床痊愈:来自一项小型、多中心、随机、前瞻性研究的中等质量证据表明,高剂量特比萘芬(500 mg,每日两次)有效,可使 87% 的淋巴皮肤型孢子丝菌病患者临床痊愈。[39]Chapman SW, Pappas P, Kauffmann C, et al. Comparative evaluation of the efficacy and safety of two doses of terbinafine (500 and 1000 mg day(-1)) in the treatment of cutaneous or lymphocutaneous sporotrichosis. Mycoses. 2004;47:62-68.http://www.ncbi.nlm.nih.gov/pubmed/14998402?tool=bestpractice.com
系统评价或者受试者>200名的随机对照临床试验(RCT)。
临床痊愈:来自一项小型、多中心、随机、前瞻性研究的中等质量证据表明,高剂量特比萘芬(500 mg,每日两次)有效,可使 87% 的淋巴皮肤型孢子丝菌病患者临床痊愈。[39]Chapman SW, Pappas P, Kauffmann C, et al. Comparative evaluation of the efficacy and safety of two doses of terbinafine (500 and 1000 mg day(-1)) in the treatment of cutaneous or lymphocutaneous sporotrichosis. Mycoses. 2004;47:62-68.http://www.ncbi.nlm.nih.gov/pubmed/14998402?tool=bestpractice.com