疫苗接种
自然感染后不产生免疫力，仍会再次感染。[26]Spinola SM, Bauer ME, Munson RS Jr. Immunopathogenesis of Haemophilus ducreyi infection (chancroid). Infect Immun. 2002 Apr;70(4):1667-76.http://iai.asm.org/content/70/4/1667.longhttp://www.ncbi.nlm.nih.gov/pubmed/11895928?tool=bestpractice.com[63]Al-Tawfiq JA, Palmer KL, Chen CY, et al. Experimental infection of human volunteers with Haemophilus ducreyi does not confer protection against subsequent challenge. J Infect Dis. 1999 May;179(5):1283-7.https://academic.oup.com/jid/article/179/5/1283/807057http://www.ncbi.nlm.nih.gov/pubmed/10191238?tool=bestpractice.com 在猪模型上，免疫接种杜克雷嗜血杆菌血红蛋白受体 HbA 显示在预防软下疳感染方面呈现出有效性。预防机制尚未明确。尚无有效的人体疫苗。[64]Afonina G, Leduc I, Nepluev I, et al. Immunization with the Haemophilus ducreyi hemoglobin receptor HgbA protects against infection in the swine model of chancroid. Infect Immun. 2006 Apr;74(4):2224-32.http://iai.asm.org/content/74/4/2224.longhttp://www.ncbi.nlm.nih.gov/pubmed/16552053?tool=bestpractice.com
单剂量抗生素联合疗法
单剂量联合治疗可能提高软下疳治疗的效果和依从性，并能降低对多剂量治疗方案的需求。在野兔模型中，已经证实头孢曲松与链霉素联用有协同作用。但支持这一结果的数据有限。[54]Roy-Leon JE, Lauzon WD, Toye B, et al. In vitro and in vivo activity of combination antimicrobial agents on Haemophilus ducreyi. J Antimicrob Chemother. 2005 Sep;56(3):552-8.https://academic.oup.com/jac/article/56/3/552/691080http://www.ncbi.nlm.nih.gov/pubmed/16046468?tool=bestpractice.com
