BMJ Best Practice
最后审核时间: 七月 2019
最近更新时间: 五月 2019

小结

定义

病史和查体

关键诊断因素

  • 哮喘、变应性鼻炎或鼻窦炎病史
  • 局灶性麻木或无力
  • 鼻腔渗出、鼻塞或面部痛
  • 高出皮面的紫癜及瘀点

其他诊断因素

  • 与用药的关系
  • 疲劳、关节痛、肌肉痛
  • 气短或咳嗽
  • 腹痛

危险因素

  • 哮喘、变应性鼻炎或鼻窦炎病史
  • 与用药的关系

诊断性检查

首要检查

  • 全血细胞计数 (FBC) 和分类计数
  • 血清抗中性粒细胞胞浆抗体(ANCA)
  • 血清 CRP
  • 红细胞沉降率
全部具体信息

需要考虑的检查

  • 流式细胞仪检测外周血
  • FIP1L1/PDGFR alpha突变的分子检测
  • 血清 IgE 水平
  • 烟曲霉血清特异性 IgE 和 IgG
全部具体信息

新兴检查

  • 心脏磁共振成像
  • 嗜酸粒细胞活化趋化因子-3
全部具体信息

治疗流程

贡献者

Assistant Professor

Division of Pulmonary and Critical Care Medicine

Mayo Clinic

Rochester

MN

利益冲突披露
KK is an author of a number of references cited in this topic and has developed educational material on Churg-Strauss syndrome for First Consult (Elsevier). KK has undertaken contractual research for GlaxoSmithKline (utilizing mepolizumab and sirukumab in asthma trials), but received no personal financial gain for this work.

Dr Karina Keogh would like to gratefully acknowledge Dr Garvan Kane, a previous contributor to this topic. GK is an author of a number of references cited in this topic.

同行评议专家 查看所有

Professor of Rheumatology

NIHR Musculoskeletal Biomedical Research Unit

Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Science

University of Oxford

Oxford

UK

利益冲突披露
RL has organisational financial interests with funds received for consultation and training on disease assessment in vasculitis for GlaxoSmithKline, Nordic, and Chemocentryx. RL has received personal funds for lectures on vasculitis from Roche and Nippon Kayaku. RL is an author of a reference cited in this topic.

Clinical Senior Lecturer in Renal Medicine

Centre for Translational Inflammation Research

University of Birmingham Research Laboratories

Queen Elizabeth Hospital Birmingham

Birmingham

UK

利益冲突披露
MDM has been a paid consultant for Sphere Medical Ltd, and has received research grants and funding from GlaxoSmithKline and Novartis.

Assistant Professor of Medicine

Division of Rheumatology

Johns Hopkins University School of Medicine

Co-Director

Johns Hopkins Vasculitis Center

Baltimore

MD

利益冲突披露
PS declares that he has no competing interests.

Professor of Clinical Rheumatology

Institute of Cellular Medicine

Newcastle University

Newcastle upon Tyne

Honorary Consultant Rheumatologist

The James Cook University Hospital

Middlesbrough

UK

利益冲突披露
JVL is consultant for Roche, the manufacturer of rituximab, and has received speaker fees and reimbursements for attending several conferences.

Associate Professor and Director

Division of Rheumatology

University of Arkansas for Medical Sciences

Little Rock

AR

利益冲突披露
RAO declares that he has no competing interests.

使用此内容应接受我们的免责声明