大多数口臭患者均有口腔原因。治疗措施主要是针对减少食物残渣堆积及产异味口腔细菌。
暂时性轻度口臭的健康患者需要提高口腔卫生。牙齿清洁即可有效去除牙菌斑，从而改善口臭。牙齿清洁包括刷牙、齿间牙线清理及轻刮舌面，[44]Ademovski SE, Persson GR, Winkel E, et al. The short-term treatment effects on the microbiota at the dorsum of the tongue in intra-oral halitosis patients - a randomized clinical trial. Clin Oral Investig. 2013;17:463-473.http://www.ncbi.nlm.nih.gov/pubmed/22573244?tool=bestpractice.com[48]Pham TA, Ueno M, Zaitsu T, et al. Clinical trial of oral malodor treatment in patients with periodontal diseases. J Periodontal Res. 2011;46:722-729.http://www.ncbi.nlm.nih.gov/pubmed/21762407?tool=bestpractice.com及使用抗菌性漱口水。
类似地，义齿也需要彻底清洁，尽管目前并没有有效的清洁方法可以减轻义齿相关口臭。[31]de Souza RF, de Freitas Oliveira Paranhos H, Lovato da Silva CH, et al. Interventions for cleaning dentures in adults. Cochrane Database Syst Rev. 2009;(4):CD007395.http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD007395.pub2/fullhttp://www.ncbi.nlm.nih.gov/pubmed/19821412?tool=bestpractice.com
舌刮目的是去除丝状乳头间残留的食物残渣、死细胞及细菌，从而降低挥发性硫化物的浓度。[11]Porter SR, Scully C. Oral malodour (halitosis). BMJ. 2006;333:632-635.http://www.ncbi.nlm.nih.gov/pubmed/16990322?tool=bestpractice.com宜在晚上用冷水和硬质牙刷或舌刮器刮舌，不需要使用牙膏。舌刮短期有效。[11]Porter SR, Scully C. Oral malodour (halitosis). BMJ. 2006;333:632-635.http://www.ncbi.nlm.nih.gov/pubmed/16990322?tool=bestpractice.com舌刮并不总是能够减少口腔内推测与口腔异味相关的细菌数量，[44]Ademovski SE, Persson GR, Winkel E, et al. The short-term treatment effects on the microbiota at the dorsum of the tongue in intra-oral halitosis patients - a randomized clinical trial. Clin Oral Investig. 2013;17:463-473.http://www.ncbi.nlm.nih.gov/pubmed/22573244?tool=bestpractice.com也没有关于为减轻口腔异味进行舌刮的最佳频率、持续时间或舌刮方法的相关证据。[49]Kuo YW, Yen M, Fetzer S, et al. Toothbrushing versus toothbrushing plus tongue cleaning in reducing halitosis and tongue coating: a systematic review and meta-analysis. Nurs Res. 2013;62:422-429.http://www.ncbi.nlm.nih.gov/pubmed/24165218?tool=bestpractice.com有相关研究结果表明添加凝胶如Meridol™（氟化铵/氟化亚锡/乳酸锌）可减轻短期口腔异味（特殊感觉测试评估）及VSCs。[50]Wilhelm D, Himmelmann A, Krause C, et al. Short term clinical efficacy of new meridol HALITOSIS tooth & tongue gel in combination with a tongue cleaner to reduce oral malodor. J Clin Dent. 2013;24:12-19.http://www.ncbi.nlm.nih.gov/pubmed/23547489?tool=bestpractice.com[51]Wilhelm D, Himmelmann A, Axmann EM, et al. Clinical efficacy of a new tooth and tongue gel applied with a tongue cleaner in reducing oral halitosis. Quintessence Int. 2012;43:709-718.http://www.ncbi.nlm.nih.gov/pubmed/23034424?tool=bestpractice.com
一系列漱口剂推荐作为口臭的治疗方法，如洗必泰、三氯苯氧氯酚及双相油水滴剂。通过减少病毒载量或减少口臭相关异味性物质而起作用。[11]Porter SR, Scully C. Oral malodour (halitosis). BMJ. 2006;333:632-635.http://www.ncbi.nlm.nih.gov/pubmed/16990322?tool=bestpractice.com规律使用漱口剂减轻口臭：目前证据尚不足，与对照组相比，规律使用含十六烷基铵基吡啶漱口剂可能在2周时减轻口臭。规律使用含氯化锌漱口剂可能在4周时减轻口臭。低质量的观察性（队列）研究或者受试者＜200名且方法学存在缺陷的随机对照临床试验（RCT）。使用加锌洗必泰能有更有效地减少舌微生物及VSCs。[44]Ademovski SE, Persson GR, Winkel E, et al. The short-term treatment effects on the microbiota at the dorsum of the tongue in intra-oral halitosis patients - a randomized clinical trial. Clin Oral Investig. 2013;17:463-473.http://www.ncbi.nlm.nih.gov/pubmed/22573244?tool=bestpractice.com亦可能加强漱口剂的美化效果。[45]Dadamio J, Van Tournout M, Teughels W, et al. Efficacy of different mouthrinse formulations in reducing oral malodour: a randomized clinical trial. J Clin Periodontol. 2013;40:505-513.http://www.ncbi.nlm.nih.gov/pubmed/23489103?tool=bestpractice.com现已证实含有葡萄糖酸锌和蜂胶的无糖甜点可以减少VSCs（由口气测量仪测定）。[46]Barak S, Katz J. The effect of Breezy candy on halitosis: a double-blind, controlled, and randomized study. Quintessence Int. 2012;43:313-317.http://www.ncbi.nlm.nih.gov/pubmed/22532945?tool=bestpractice.com
其他可在数小时内减轻口臭的配方包括含有氯化十六烷吡啶、二氧化氯及氯化锌的漱口剂，[41]Borden LC, Chaves ES, Bowman JP, et al. The effect of four mouthrinses on oral malodor. Compend Contin Educ Dent. 2002;23:531-536.http://www.ncbi.nlm.nih.gov/pubmed/12789968?tool=bestpractice.com[42]Frascella J, Gilbert RD, Fernandez P, et al. Efficacy of a chlorine dioxide-containing mouthrinse in oral malodor. Compend Contin Educ Dent. 2000;21:241-244.http://www.ncbi.nlm.nih.gov/pubmed/11199703?tool=bestpractice.com单次使用漱口剂口臭口臭：目前证据尚不足，与对照组相比，单次使用漱口剂可在使用后1-8小时内减轻口臭程度和不适。单次使用含有氯化十六烷吡啶的漱口剂在使用后4小时内效果优于使用蒸馏水或安慰剂。低质量的观察性（队列）研究或者受试者＜200名且方法学存在缺陷的随机对照临床试验（RCT）。及稳定的氟化亚锡六聚偏磷酸钠（0.454%）。[43]Farrell S, Barker ML, Gerlach RW. Overnight malodor effect with a 0.454% stabilized stannous fluoride sodium hexametaphosphate dentifrice. Compend Contin Educ Dent. 2007;28:658-661.http://www.ncbi.nlm.nih.gov/pubmed/18186171?tool=bestpractice.com
然而，目前只有少数几个研究以上所述漱口剂有效性的随机临床试验。
