这是少数主要影响男性的原发性头痛之一(男女患者比例为2.5:1-3.5:1)。[1]Bahra A, May A, Goadsby PJ. Cluster headache: a prospective clinical study with diagnostic implications. Neurology. 2002 Feb 12;58(3):354-61.http://www.ncbi.nlm.nih.gov/pubmed/11839832?tool=bestpractice.com[6]Manzoni GC. Gender ratio of cluster headache over the years: a possible role of changes in lifestyle. Cephalalgia. 1998;18:138-142.http://www.ncbi.nlm.nih.gov/pubmed/9595206?tool=bestpractice.com[7]Bahra A, Gawel MJ, Hardebo JE, et al. Oral zolmitriptan is effective in the acute treatment of cluster headache. Neurology. 2000 May 9;54(9):1832-9.http://www.ncbi.nlm.nih.gov/pubmed/10802793?tool=bestpractice.com 研究表明,丛集性头痛的患病率可能至少为 1/500,[8]Russell MB. Epidemiology and genetics of cluster headache. Lancet Neurol. 2004 May;3(5):279-83.http://www.ncbi.nlm.nih.gov/pubmed/15099542?tool=bestpractice.com 在头痛门诊患者中,丛集性头痛所占的比例为 8%-10%。[9]Manzoni GC, Micieli G, Granella F, et al. Cluster headache - course over ten years in 189 patients. Cephalalgia. 1991;11:169-174.http://www.ncbi.nlm.nih.gov/pubmed/1742772?tool=bestpractice.com 发病年龄通常为20-40岁。 据报告,尽管这种情况极为罕见,曾经有年仅6岁的儿童出现丛集性头痛。 大约90%的丛集性头痛患者为偶发性丛集性头痛;10%的患者的疼痛开始即不间断(原发性慢性丛集性头痛)。[10]Dodick DW, Rozen TD, Goadsby PJ, et al. Cluster headache. Cephalalgia. 2000;20:787-803.http://www.ncbi.nlm.nih.gov/pubmed/11167909?tool=bestpractice.com