地高辛免疫Fab给药后,血清地高辛浓度(SDC)通常会假性升高(10~30倍)。服药3~4天后,可重新测量血清地高辛浓度。[31]Lemon M, Andrews DJ, Binks AM, et al. Concentrations of free serum digoxin after treatment with antibody fragments. Br Med J (Clin Res Ed). 1987;295:1520-1521.http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1248668/pdf/bmjcred00050-0022.pdfhttp://www.ncbi.nlm.nih.gov/pubmed/3122885?tool=bestpractice.com[32]Miller JJ, Straub RW Jr, Valdes R Jr. Analytical performance of a monoclonal digoxin assay with increased specificity on the ACS:180. Ther Drug Monit. 1996;18:65-72.http://www.ncbi.nlm.nih.gov/pubmed/8848824?tool=bestpractice.com[33]Rainey PM. Effects of digoxin immune Fab (ovine) on digoxin immunoassays. Am J Clin Pathol. 1989;92:779-786.http://www.ncbi.nlm.nih.gov/pubmed/2686397?tool=bestpractice.com但已有报告称,血清地高辛浓度升高可长达 10 天,尤其是在肾功能不全的患者中。[32]Miller JJ, Straub RW Jr, Valdes R Jr. Analytical performance of a monoclonal digoxin assay with increased specificity on the ACS:180. Ther Drug Monit. 1996;18:65-72.http://www.ncbi.nlm.nih.gov/pubmed/8848824?tool=bestpractice.com