如果不进行治疗， Whipple 病是将会导致死亡的慢性传染性疾病，通过抗生素治疗，患者通常会完全治愈。但是，患者可能会出现不可逆的 CNS 或关节损伤，而且这一问题会持续存在，这与细菌定植无关。甲氧苄啶/磺胺甲基异恶唑耐药罕见。[83]Fenollar F, Rolain JM, Alric L, et al. Resistance to trimethoprim/sulfamethoxazole and Tropheryma whipplei. Int J Antimicrob Agents. 2009;34:255-259.http://www.ncbi.nlm.nih.gov/pubmed/19346107?tool=bestpractice.com[84]Lagier JC, Fenollar F, Lepidi H, et al. Failure and relapse after treatment with trimethoprim/sulfamethoxazole in classic Whipple's disease. J Antimicrob Chemother. 2010;65:2005-2012.http://www.ncbi.nlm.nih.gov/pubmed/20639526?tool=bestpractice.com如有发生，应使用替代治疗。治疗不充分，Whipple 病会复发，导致疾病进展更严重，尤其是累及 CNS。[85]Marumganti AR, Murphy TF. Whipple's disease: neurological relapse presenting as headache for two years. J Gen Intern Med. 2008;23:2131-2133.http://www.ncbi.nlm.nih.gov/pubmed/18784966?tool=bestpractice.com[86]Garas G, Cheng WS, Abrugiato R, et al. Clinical relapse in Whipple's disease despite maintenance therapy. J Gastroenterol Hepatol. 2000;15:1223-1226.http://www.ncbi.nlm.nih.gov/pubmed/11106107?tool=bestpractice.com
