1999 年,在挪威开展的一项关于 Addison 病的流行病学研究显示,此病的患病率为 140/100 万,并且在过去十年内记录的平均发病率为 0.62/10 万。[2]Løvås K, Husebye ES. High prevalence and increasing incidence of Addison's disease in western Norway. Clin Endocrinol (Oxf). 2002 Jun;56(6):787-91.http://www.ncbi.nlm.nih.gov/pubmed/12072049?tool=bestpractice.com 1996 年美国受累患者数估计为 13,300 人(其中 92% 为女性)。[3]Jacobson DL, Gange SJ, Rose NR, et al. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol. 1997 Sep;84(3):223-43.http://www.ncbi.nlm.nih.gov/pubmed/9281381?tool=bestpractice.com 在欧洲发达国家,总体患病率从 20 世纪 60 年代的 40-70 例/100 万人增加到 140 例/100 万人以上。[4]Arlt W, Allolio B. Adrenal insufficiency. Lancet. 2003 May 31;361(9372):1881-93.http://www.ncbi.nlm.nih.gov/pubmed/12788587?tool=bestpractice.com[5]Charmandari E, Nicolaides NC, Chrousos GP. Adrenal insufficiency. Lancet. 2014 Jun 21;383(9935):2152-67.http://www.ncbi.nlm.nih.gov/pubmed/24503135?tool=bestpractice.com 全世界的年发病率在 4.7/100 万至 6.2/100 万之间变化。[3]Jacobson DL, Gange SJ, Rose NR, et al. Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clin Immunol Immunopathol. 1997 Sep;84(3):223-43.http://www.ncbi.nlm.nih.gov/pubmed/9281381?tool=bestpractice.com[5]Charmandari E, Nicolaides NC, Chrousos GP. Adrenal insufficiency. Lancet. 2014 Jun 21;383(9935):2152-67.http://www.ncbi.nlm.nih.gov/pubmed/24503135?tool=bestpractice.com