预防口腔白斑,首先是要去除典型的危险因素(如吸烟、咀嚼槟榔和饮酒)。[49]Petti S, Scully C. The role of the dental team in preventing and diagnosing oral cancer: 5. Alcohol and the role of the dentist in alcohol cessation. Dent Update. 2005;32:454-455;458-460;462.http://www.ncbi.nlm.nih.gov/pubmed/16262033?tool=bestpractice.com[50]Shiu MN, Chen TH. Impact of betel quid, tobacco and alcohol on three-stage disease natural history of oral leukoplakia and cancer: implication for prevention of oral cancer. Eur J Cancer Prev. 2004;13:39-45.http://www.ncbi.nlm.nih.gov/pubmed/15075787?tool=bestpractice.com然而,很多口腔白斑是特发性的。