区别眶周和眶蜂窝织炎非常重要,因为后者的发病率更高。眶周蜂窝织炎的诊断基于病史和全面的眼科检查。眼肌麻痹、眼球突出以及视力障碍是眶蜂窝织炎的关键特征性表现。进行眼眶CT或MRI检查有助于确诊。两种疾病的病原体培养往往呈阴性,但对于易取样的病例,治疗前取样也可能培养成功。此外,应进行鼻咽部和结膜的病原体培养。但在大多数情况下取样前已经开始经验性治疗。
疾病史
全面的病史,除了现病史的相关问题,还应包括近期或现症感染(尤其是鼻窦、牙齿或耳部的感染),睑腺炎/睑板腺囊肿,穿通伤以及昆虫叮咬史等。潜在的鼻窦炎是眶蜂窝织炎的最主要原因。儿童患者往往同时伴有隔前蜂窝织炎。[1]Robinson A, Beech T, McDermott AL, et al. Investigation and management of adult periorbital or orbital cellulitis. J Laryngol Otol. 2007;121:545-547.http://www.ncbi.nlm.nih.gov/pubmed/17164026?tool=bestpractice.com[11]Schramm VL, Myers EN, Kennerdell JS. Orbital complications of acute sinusitis: evaluation, management, and outcome. Otolaryngology. 1978;86:221-230.诊断时应除外眼外伤,包括直接或间接眼外伤(眼内异物、眶壁骨折)。一些患者在进行眼部手术特别是斜视术后出现类似症状。[1]Robinson A, Beech T, McDermott AL, et al. Investigation and management of adult periorbital or orbital cellulitis. J Laryngol Otol. 2007;121:545-547.http://www.ncbi.nlm.nih.gov/pubmed/17164026?tool=bestpractice.com[3]Powell KR. Orbital and periorbital cellulitis. Pediatr Rev. 1995;16:163-167.http://www.ncbi.nlm.nih.gov/pubmed/7753730?tool=bestpractice.com[4]Chandler JR, Langenbrunner DJ, Stevens ER. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope. 1970;80:1414-1428.http://www.ncbi.nlm.nih.gov/pubmed/5470225?tool=bestpractice.com[5]Kloek CE, Rubin PA. Role of inflammation in orbital cellulitis. Int Ophthalmol Clin. 2006;46:57-68.http://www.ncbi.nlm.nih.gov/pubmed/ 16770154?tool=bestpractice.com
同时要注意询问是否有乙型流感嗜血杆菌疫苗的接种史。
眶周蜂窝织炎通常表现为眼睑周围发红,不伴明显的疼痛、压痛、肿胀或发热。
[Figure caption and citation for the preceding image starts]: 左眼睑潮红肿胀来自加州大学旧金山分校 (UCSF) 医学博士 H. Jane Kim 和医学博士 Robert Kersten 的个人收藏;经许可后使用 [Citation ends].眼眶蜂窝织炎通常表现为眼睑周围严重发红,伴肿胀和压痛。多伴有眼、耳或面部疼痛,乏力,头痛及发热。出现恶心/呕吐和嗜睡的症状提示脑膜可能受累。[1]Robinson A, Beech T, McDermott AL, et al. Investigation and management of adult periorbital or orbital cellulitis. J Laryngol Otol. 2007;121:545-547.http://www.ncbi.nlm.nih.gov/pubmed/17164026?tool=bestpractice.com[3]Powell KR. Orbital and periorbital cellulitis. Pediatr Rev. 1995;16:163-167.http://www.ncbi.nlm.nih.gov/pubmed/7753730?tool=bestpractice.com[4]Chandler JR, Langenbrunner DJ, Stevens ER. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope. 1970;80:1414-1428.http://www.ncbi.nlm.nih.gov/pubmed/5470225?tool=bestpractice.com[5]Kloek CE, Rubin PA. Role of inflammation in orbital cellulitis. Int Ophthalmol Clin. 2006;46:57-68.http://www.ncbi.nlm.nih.gov/pubmed/ 16770154?tool=bestpractice.com
查体
应进行全面的眼科检查和头颈部检查,查找可能的感染源,如眼部被蚊虫叮咬,牙齿感染或淋巴结肿大。眼睑水肿和红斑在隔前蜂窝织炎和眶蜂窝织炎中常见。儿童患者的视力难以测定。眶压升高常引起视力下降,因此要注意检查是否存在传入性瞳孔障碍。[1]Robinson A, Beech T, McDermott AL, et al. Investigation and management of adult periorbital or orbital cellulitis. J Laryngol Otol. 2007;121:545-547.http://www.ncbi.nlm.nih.gov/pubmed/17164026?tool=bestpractice.com[3]Powell KR. Orbital and periorbital cellulitis. Pediatr Rev. 1995;16:163-167.http://www.ncbi.nlm.nih.gov/pubmed/7753730?tool=bestpractice.com[4]Chandler JR, Langenbrunner DJ, Stevens ER. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope. 1970;80:1414-1428.http://www.ncbi.nlm.nih.gov/pubmed/5470225?tool=bestpractice.com[5]Kloek CE, Rubin PA. Role of inflammation in orbital cellulitis. Int Ophthalmol Clin. 2006;46:57-68.http://www.ncbi.nlm.nih.gov/pubmed/ 16770154?tool=bestpractice.com眶蜂窝织炎可出现眼压增高,这反映了水肿所致的眶压升高。升高的眶压可迅速导致视力下降,是进行急诊手术的指征。眼肌麻痹和眼球突出也是诊断眶蜂窝织炎的重要依据。若出现双侧眼眶受累的征象,包括三叉神经眼支或上颌支受累和眼肌麻痹,应检查是否存在海绵窦血栓形成。若疑为毛霉菌病(如免疫功能低下或糖尿病患者),则应检查口腔和鼻腔顶部是否存在组织坏死和黑色焦痂(晚期表现)。
实验室检查
可疑眶周蜂窝织炎或眶蜂窝织炎时,应进行白细胞计数、血培养以及结膜、鼻咽部或皮肤伤口处的微生物拭子检测。[1]Robinson A, Beech T, McDermott AL, et al. Investigation and management of adult periorbital or orbital cellulitis. J Laryngol Otol. 2007;121:545-547.http://www.ncbi.nlm.nih.gov/pubmed/17164026?tool=bestpractice.com[3]Powell KR. Orbital and periorbital cellulitis. Pediatr Rev. 1995;16:163-167.http://www.ncbi.nlm.nih.gov/pubmed/7753730?tool=bestpractice.com[4]Chandler JR, Langenbrunner DJ, Stevens ER. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope. 1970;80:1414-1428.http://www.ncbi.nlm.nih.gov/pubmed/5470225?tool=bestpractice.com[5]Kloek CE, Rubin PA. Role of inflammation in orbital cellulitis. Int Ophthalmol Clin. 2006;46:57-68.http://www.ncbi.nlm.nih.gov/pubmed/ 16770154?tool=bestpractice.com培养的阳性率为0%~33%。[12]Dudin A, Othman A. Acute periorbital swelling: evaluation of management protocol. Pediatr Emerg Care. 1996;12:16-20.http://www.ncbi.nlm.nih.gov/pubmed/8677172?tool=bestpractice.com儿童患者的阳性率高于成人患者。[13]Patt BS, Manning SC. Blindness resulting from orbital complications of sinusitis. Otolaryngol Head Neck Surg. 1991;104:789-795.http://www.ncbi.nlm.nih.gov/pubmed/1908969?tool=bestpractice.com[11]Schramm VL, Myers EN, Kennerdell JS. Orbital complications of acute sinusitis: evaluation, management, and outcome. Otolaryngology. 1978;86:221-230.如果出现脑膜刺激征,建议进行腰椎穿刺。[6]Swift AC, Charlton G. Sinusitis and the acute orbit in children. J Laryngol Otol. 1990;104:213-216.http://www.ncbi.nlm.nih.gov/pubmed/2187942?tool=bestpractice.com[7]Howe L, Jones NS. Guidelines for the management of periorbital cellulitis/abscess. Clin Otolaryngol Allied Sci. 2004;29:725-728.http://www.ncbi.nlm.nih.gov/pubmed/15533168?tool=bestpractice.com
影像学检查
对于可疑眶蜂窝织炎的患者,CT增强扫描是主要诊断方法,可发现鼻旁窦病变或骨膜下脓肿。[1]Robinson A, Beech T, McDermott AL, et al. Investigation and management of adult periorbital or orbital cellulitis. J Laryngol Otol. 2007;121:545-547.http://www.ncbi.nlm.nih.gov/pubmed/17164026?tool=bestpractice.com[3]Powell KR. Orbital and periorbital cellulitis. Pediatr Rev. 1995;16:163-167.http://www.ncbi.nlm.nih.gov/pubmed/7753730?tool=bestpractice.com[4]Chandler JR, Langenbrunner DJ, Stevens ER. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope. 1970;80:1414-1428.http://www.ncbi.nlm.nih.gov/pubmed/5470225?tool=bestpractice.com[5]Kloek CE, Rubin PA. Role of inflammation in orbital cellulitis. Int Ophthalmol Clin. 2006;46:57-68.http://www.ncbi.nlm.nih.gov/pubmed/ 16770154?tool=bestpractice.com如果有临床症状表现,MRI检查可以用来排除颅内脓肿和海绵窦血栓形成。[6]Swift AC, Charlton G. Sinusitis and the acute orbit in children. J Laryngol Otol. 1990;104:213-216.http://www.ncbi.nlm.nih.gov/pubmed/2187942?tool=bestpractice.com
转诊
如果患者出现眶周水肿和眼睑潮红伴视力障碍,应就诊于眼整形科。[1]Robinson A, Beech T, McDermott AL, et al. Investigation and management of adult periorbital or orbital cellulitis. J Laryngol Otol. 2007;121:545-547.http://www.ncbi.nlm.nih.gov/pubmed/17164026?tool=bestpractice.com[3]Powell KR. Orbital and periorbital cellulitis. Pediatr Rev. 1995;16:163-167.http://www.ncbi.nlm.nih.gov/pubmed/7753730?tool=bestpractice.com[4]Chandler JR, Langenbrunner DJ, Stevens ER. The pathogenesis of orbital complications in acute sinusitis. Laryngoscope. 1970;80:1414-1428.http://www.ncbi.nlm.nih.gov/pubmed/5470225?tool=bestpractice.com[5]Kloek CE, Rubin PA. Role of inflammation in orbital cellulitis. Int Ophthalmol Clin. 2006;46:57-68.http://www.ncbi.nlm.nih.gov/pubmed/ 16770154?tool=bestpractice.com