基因分型作为诊断工具：有中等质量证据表明所有具有CC_13910/GG_22018 基因型的有症状患者存在乳糖不耐受；82%具有CT_13910/GA_22018基因型的有症状患者存在乳糖不耐受；68%具有TT_13910/AA_22018基因型的有症状患者存在乳糖不耐受。[1]Matthews SB, Waud JP, Roberts AG, et al. Systemic lactose intolerance: a new perspective on an old problem. Postgrad Med J. 2005 Mar;81(953):167-73.https://pmj.bmj.com/content/81/953/167.longhttp://www.ncbi.nlm.nih.gov/pubmed/15749792?tool=bestpractice.com
系统评价或者受试者＞200名的随机对照临床试验（RCT）。
基因分型作为诊断工具：有中等质量证据表明所有具有CC_13910/GG_22018 基因型的有症状患者存在乳糖不耐受；82%具有CT_13910/GA_22018基因型的有症状患者存在乳糖不耐受；68%具有TT_13910/AA_22018基因型的有症状患者存在乳糖不耐受。[1]Matthews SB, Waud JP, Roberts AG, et al. Systemic lactose intolerance: a new perspective on an old problem. Postgrad Med J. 2005 Mar;81(953):167-73.https://pmj.bmj.com/content/81/953/167.longhttp://www.ncbi.nlm.nih.gov/pubmed/15749792?tool=bestpractice.com
可被耐受的乳糖量：有中等质量的证据显示声称有严重的乳糖不耐受的乳糖吸收不良者可以耐受每日240mL牛奶，仅有轻微不耐受症状。[57]Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. N Engl J Med. 1995 Jul 6;333(1):1-4.https://www.nejm.org/doi/10.1056/NEJM199507063330101http://www.ncbi.nlm.nih.gov/pubmed/7776987?tool=bestpractice.com
系统评价或者受试者＞200名的随机对照临床试验（RCT）。
可被耐受的乳糖量：有中等质量的证据显示声称有严重的乳糖不耐受的乳糖吸收不良者可以耐受每日240mL牛奶，仅有轻微不耐受症状。[57]Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. N Engl J Med. 1995 Jul 6;333(1):1-4.https://www.nejm.org/doi/10.1056/NEJM199507063330101http://www.ncbi.nlm.nih.gov/pubmed/7776987?tool=bestpractice.com
含乳糖配方奶和母乳的应用：有中等质量的证据显示含乳糖配方奶和母乳对有发育性乳糖酶缺乏的早产婴儿无短期或长期的有害影响。[66]Erasmus HD, Ludwig-Auser HM, Paterson PG, et al. Enhanced weight gain in preterm infants receiving lactase-treated feeds: a randomized, double-blind, controlled trial. J Pediatr. 2002 Oct;141(4):532-7.http://www.ncbi.nlm.nih.gov/pubmed/12378193?tool=bestpractice.com
系统评价或者受试者＞200名的随机对照临床试验（RCT）。
含乳糖配方奶和母乳的应用：有中等质量的证据显示含乳糖配方奶和母乳对有发育性乳糖酶缺乏的早产婴儿无短期或长期的有害影响。[66]Erasmus HD, Ludwig-Auser HM, Paterson PG, et al. Enhanced weight gain in preterm infants receiving lactase-treated feeds: a randomized, double-blind, controlled trial. J Pediatr. 2002 Oct;141(4):532-7.http://www.ncbi.nlm.nih.gov/pubmed/12378193?tool=bestpractice.com
短期使用乳糖酶补充剂或低乳糖配方奶：有中等质量证据显示出现发育性乳糖酶缺乏的早产婴儿短期使用乳糖酶补充剂或低乳糖配方奶可获益。[2]Heyman MB; American Academy of Pediatrics, Committee on Nutrition. Lactose intolerance in infants, children, and adolescents. Pediatrics. 2006 Sep;118(3):1279-86.http://pediatrics.aappublications.org/content/118/3/1279.longhttp://www.ncbi.nlm.nih.gov/pubmed/16951027?tool=bestpractice.com
系统评价或者受试者＞200名的随机对照临床试验（RCT）。
短期使用乳糖酶补充剂或低乳糖配方奶：有中等质量证据显示出现发育性乳糖酶缺乏的早产婴儿短期使用乳糖酶补充剂或低乳糖配方奶可获益。[2]Heyman MB; American Academy of Pediatrics, Committee on Nutrition. Lactose intolerance in infants, children, and adolescents. Pediatrics. 2006 Sep;118(3):1279-86.http://pediatrics.aappublications.org/content/118/3/1279.longhttp://www.ncbi.nlm.nih.gov/pubmed/16951027?tool=bestpractice.com
