嘌呤类似物治疗极大地改善了HCL患者的无疾病进展生存。[81]BCSH Blood Transfusion Task Force. Guidelines on gamma irradiation of blood components for the prevention of transfusion-associated graft-versus-host disease. Transfus Med. 1996 Sep;6(3):261-71.http://www.ncbi.nlm.nih.gov/pubmed/8885157?tool=bestpractice.com[85]Robak T, Jamroziak K, Gora-Tybor J, et al. Cladribine in a weekly versus daily schedule for untreated active hairy cell leukemia: final report from the Polish Adult Leukemia Group (PALG) of a prospective, randomized, multicenter trial. Blood. 2007 May 1;109(9):3672-5.http://bloodjournal.hematologylibrary.org/cgi/content/full/109/9/3672http://www.ncbi.nlm.nih.gov/pubmed/17209059?tool=bestpractice.com 大多数（约 96%）HCL 患者对初始嘌呤类似物治疗有反应。[63]Maevis V, Mey U, Schmidt-Wolf G, et al. Hairy cell leukemia: short review, today's recommendations and outlook. Blood Cancer J. 2014 Feb 14;4:e184.https://www.nature.com/articles/bcj20143http://www.ncbi.nlm.nih.gov/pubmed/24531447?tool=bestpractice.com 然而，大约 30%-40% 的 HCL 患者在初始治疗后复发。[64]Chadha P, Rademaker AW, Mendiratta P, et al. Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience. Blood. 2005 Jul 1;106(1):241-6.http://bloodjournal.hematologylibrary.org/cgi/content/full/106/1/241http://www.ncbi.nlm.nih.gov/pubmed/15761021?tool=bestpractice.com[65]Else M, Dearden CE, Matutes E, et al. Long-term follow-up of 233 patients with hairy cell leukaemia, treated initially with pentostatin or cladribine, at a median of 16 years from diagnosis. Br J Haematol. 2009 Jun;145(6):733-40.http://www.ncbi.nlm.nih.gov/pubmed/19344416?tool=bestpractice.com大多数 HCL 患者有望在诊断后生存 10 年或更久。[46]Goodman GR, Burian C, Koziol JA, et al. Extended follow-up of patients with hairy cell leukemia after treatment with cladribine. J Clin Oncol. 2003 Mar 1;21(5):891-6.http://www.ncbi.nlm.nih.gov/pubmed/12610190?tool=bestpractice.com[35]Flinn IW, Kopecky KJ, Foucar MK, et al. Long-term follow-up of remission duration, mortality, and second malignancies in hairy cell leukemia patients treated with pentostatin. Blood. 2000 Nov 1;96(9):2981-6.http://bloodjournal.hematologylibrary.org/cgi/content/full/96/9/2981http://www.ncbi.nlm.nih.gov/pubmed/11049974?tool=bestpractice.com[64]Chadha P, Rademaker AW, Mendiratta P, et al. Treatment of hairy cell leukemia with 2-chlorodeoxyadenosine (2-CdA): long-term follow-up of the Northwestern University experience. Blood. 2005 Jul 1;106(1):241-6.http://bloodjournal.hematologylibrary.org/cgi/content/full/106/1/241http://www.ncbi.nlm.nih.gov/pubmed/15761021?tool=bestpractice.com
