meta 分析显示,早绝经对心血管疾病总体上有一定影响。[49]Snowdon DA, Kane RL, Beeson WL, et al. Is early natural menopause a biologic marker of health and aging? Am J Public Health. 1989;79:709-714.http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=1349628&blobtype=pdfhttp://www.ncbi.nlm.nih.gov/pubmed/2729468?tool=bestpractice.comPOF 发病越早,与心血管并发症之间的关联就越强(主要是由于冠状动脉疾病和卒中)。据一项研究记载,POF 女性的死亡率会增加一倍,即使补充雌激素也无法改变。[6]Shuster LT, Gostout BS, Grossardt BR, et al. Prophylactic oophorectomy in premenopausal women and long-term health - a review. Menopause Int. 2008;14:111-116.http://www.pubmedcentral.nih.gov/picrender.fcgi?artid=2585770&blobtype=pdfhttp://www.ncbi.nlm.nih.gov/pubmed/18714076?tool=bestpractice.com
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