年发病率约为 6/10万。[1]American Thoracic Society. Statement on sarcoidosis: joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG), adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160:736-755.http://www.atsjournals.org/doi/full/10.1164/ajrccm.160.2.ats4-99http://www.ncbi.nlm.nih.gov/pubmed/10430755?tool=bestpractice.com在美国，黑人结节病的终生风险略高于白人。[1]American Thoracic Society. Statement on sarcoidosis: joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG), adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160:736-755.http://www.atsjournals.org/doi/full/10.1164/ajrccm.160.2.ats4-99http://www.ncbi.nlm.nih.gov/pubmed/10430755?tool=bestpractice.com斯堪的纳维亚人也有较高的发病率。[1]American Thoracic Society. Statement on sarcoidosis: joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG), adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160:736-755.http://www.atsjournals.org/doi/full/10.1164/ajrccm.160.2.ats4-99http://www.ncbi.nlm.nih.gov/pubmed/10430755?tool=bestpractice.com胸腔外表现在特定人群中更为常见，例如美国黑人常出现慢性葡萄膜炎、波多黎各人常出现冻疮样狼疮、欧洲人常出现结节性红斑。[1]American Thoracic Society. Statement on sarcoidosis: joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG), adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160:736-755.http://www.atsjournals.org/doi/full/10.1164/ajrccm.160.2.ats4-99http://www.ncbi.nlm.nih.gov/pubmed/10430755?tool=bestpractice.com心脏和眼部结节病在日本似乎更常见。据观察，结节病患者的一级和二级亲属患结节病的风险明显升高。[2]Rybicki BA, Iannuzzi MC, Frederick MM, et al. Familial aggregation of sarcoidosis: a case-control etiologic study of sarcoidosis (ACCESS). Am J Respir Crit Care Med. 2001;164:2085-2091.http://www.atsjournals.org/doi/full/10.1164/ajrccm.164.11.2106001http://www.ncbi.nlm.nih.gov/pubmed/11739139?tool=bestpractice.com女性更可能出现眼睛和神经系统受累、结节性红斑，而男性更可能出现高钙血症。黑人更可能出现皮肤表现（而非结节性红斑）以及眼睛、肝脏、骨髓和胸腔外淋巴结受累。[3]Baughman RP, Teirstein AS, Judson MA, et al. Clinical characteristics of patients in a case control study of sarcoidosis. Am J Respir Crit Care Med. 2001;164:1885-1889.http://www.atsjournals.org/doi/full/10.1164/ajrccm.164.10.2104046http://www.ncbi.nlm.nih.gov/pubmed/11734441?tool=bestpractice.com
