结节病

初始表现最常见于此年龄段。[1]American Thoracic Society. Statement on sarcoidosis: joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG), adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160:736-755.http://www.atsjournals.org/doi/full/10.1164/ajrccm.160.2.ats4-99http://www.ncbi.nlm.nih.gov/pubmed/10430755?tool=bestpractice.com

结节病患者的一级和二级亲属的患病风险明显升高。证据 B结节病风险：有中等质量的证据显示，与对照组亲属相比，已确诊的结节病患者的一级和二级亲属患结节病的风险显著升高。[2]Rybicki BA, Iannuzzi MC, Frederick MM, et al. Familial aggregation of sarcoidosis: a case-control etiologic study of sarcoidosis (ACCESS). Am J Respir Crit Care Med. 2001;164:2085-2091.http://www.atsjournals.org/doi/full/10.1164/ajrccm.164.11.2106001http://www.ncbi.nlm.nih.gov/pubmed/11739139?tool=bestpractice.com受试者＜200名的随机对照临床试验（RCT）、受试者＞200名且方法学存在缺陷的随机对照临床试验（RCT）、方法学存在缺陷的系统评价或者高质量的观察性（队列）研究。

斯堪的纳维亚人发病率较高。[1]American Thoracic Society. Statement on sarcoidosis: joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG), adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160:736-755.http://www.atsjournals.org/doi/full/10.1164/ajrccm.160.2.ats4-99http://www.ncbi.nlm.nih.gov/pubmed/10430755?tool=bestpractice.com

女性患病率稍高，不同族群之间存在差异。[1]American Thoracic Society. Statement on sarcoidosis: joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG), adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160:736-755.http://www.atsjournals.org/doi/full/10.1164/ajrccm.160.2.ats4-99http://www.ncbi.nlm.nih.gov/pubmed/10430755?tool=bestpractice.com

与吸烟者相比，似乎更常见于非吸烟者。[4]Valeyre D, Soler P, Clerici C, et al. Smoking and pulmonary sarcoidosis: effect of cigarette smoking on prevalence, clinical manifestations, alveolitis, and evolution of the disease. Thorax. 1988;43:516-524.http://www.ncbi.nlm.nih.gov/pubmed/2850637?tool=bestpractice.com

在美国，黑人结节病的终生风险略高于白人。在美国，慢性葡萄膜炎在黑人中更为常见。

冻疮样狼疮在波多黎各人中更常见。

结节性红斑在欧洲人中更常见。[1]American Thoracic Society. Statement on sarcoidosis: joint statement of the American Thoracic Society (ATS), the European Respiratory Society (ERS) and the World Association of Sarcoidosis and Other Granulomatous Disorders (WASOG), adopted by the ATS Board of Directors and by the ERS Executive Committee, February 1999. Am J Respir Crit Care Med. 1999;160:736-755.http://www.atsjournals.org/doi/full/10.1164/ajrccm.160.2.ats4-99http://www.ncbi.nlm.nih.gov/pubmed/10430755?tool=bestpractice.com