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锌缺乏症可加重急性和慢性感染，进而又加重锌缺乏症。锌补充剂在治疗腹泻方面的作用已经明确；虽然有限但越来越多的证据表明锌补充剂在包括疟疾和肺炎在内的其他感染病例中的功效，[23]Fischer Walker C, Black RE. Zinc and the risk for infectious disease. Annu Rev Nutr. 2004;24:255-275.http://www.ncbi.nlm.nih.gov/pubmed/15189121?tool=bestpractice.com[66]Lazzerini M, Ronfani L. Oral zinc for treating diarrhoea in children. Cochrane Database Syst Rev. 2013;(1):CD005436.http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005436.pub4/fullhttp://www.ncbi.nlm.nih.gov/pubmed/23440801?tool=bestpractice.com[71]Haider BA, Bhutta ZA. The effect of therapeutic zinc supplementation among young children with selected infections: a review of the evidence. Food Nutr Bull. 2009;30(1 suppl):S41-S59.http://www.ncbi.nlm.nih.gov/pubmed/19472601?tool=bestpractice.com尽管不被所有试验结果支持。[72]Valentiner-Branth P, Shrestha PS, Chandyo RK, et al. A randomized controlled trial of the effect of zinc as adjuvant therapy in children 2-35 mo of age with severe or nonsevere pneumonia in Bhaktapur, Nepal. Am J Clin Nutr. 2010;91:1667-1674.http://www.ncbi.nlm.nih.gov/pubmed/20375190?tool=bestpractice.com[73]Yakoob MY, Theodoratou E, Jabeen A, et al. Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria. BMC Public Health. 2011;11(suppl 3):S23.http://bmcpublichealth.biomedcentral.com/articles/10.1186/1471-2458-11-S3-S23http://www.ncbi.nlm.nih.gov/pubmed/21501441?tool=bestpractice.com
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