非典型细菌病原体是下呼吸道疾病(包括社区获得性肺炎)的相对常见原因。[1]Marchello C, Dale AP, Thai TN, et al. Prevalence of atypical pathogens in patients with cough and community-acquired pneumonia: a meta-analysis. Ann Fam Med. 2016;14:552-566.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389400/http://www.ncbi.nlm.nih.gov/pubmed/28376442?tool=bestpractice.com在全球的社区获得性肺炎中,非典型病原体的发生率大约为 22%,但随地区而变化。[2]Arnold FW, Summersgill JT, Ramirez JA. Role of atypical pathogens in the etiology of community-acquired pneumonia. Semin Respir Crit Care Med. 2016;37:819-828.https://www.thieme-connect.com/products/ejournals/html/10.1055/s-0036-1592121http://www.ncbi.nlm.nih.gov/pubmed/27960206?tool=bestpractice.com
高达20%的社区获得性肺炎病例由肺炎支原体感染引起,并且肺炎支原体还可以导致一些医院内流行性感染。感染常见于儿童和年轻成人,并且往往见于封闭式社区环境,例如寄宿学校、大学和军事基地。[3]Jain S, Williams DJ, Arnold SR, et al; CDC EPIC Study Team. Community-acquired pneumonia requiring hospitalization among US children. N Engl J Med. 2015;372:835-845.http://www.nejm.org/doi/full/10.1056/NEJMoa1405870#t=articlehttp://www.ncbi.nlm.nih.gov/pubmed/25714161?tool=bestpractice.com在夏季末或秋季,发病率相对增加。每隔 3 至 6 年会发生疫情。[1]Marchello C, Dale AP, Thai TN, et al. Prevalence of atypical pathogens in patients with cough and community-acquired pneumonia: a meta-analysis. Ann Fam Med. 2016;14:552-566.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389400/http://www.ncbi.nlm.nih.gov/pubmed/28376442?tool=bestpractice.com先前暴露于病原体具有保护性作用,而吸烟会增加感染风险。[4]Waites KB, Talkington DF. Mycoplasma pneumoniae and its role as a human pathogen. Clin Microbiol Rev. 2004;17:697-728.http://www.ncbi.nlm.nih.gov/pubmed/15489344?tool=bestpractice.com[5]File TM. Community-acquired pneumonia. Lancet. 2003;362:1991-2001.http://www.ncbi.nlm.nih.gov/pubmed/14683661?tool=bestpractice.com[6]Klement E, Talkington DF, Wasserzug O, et al. Identification of risk factors for infection in an outbreak of Mycoplasma pneumoniae respiratory tract disease. Clin Infect Dis. 2006;43:1239-1245.http://www.ncbi.nlm.nih.gov/pubmed/17051486?tool=bestpractice.com[7]Feikin DR, Moroney JF, Talkington DF, et al. An outbreak of acute respiratory disease caused by Mycoplasma pneumoniae and adenovirus at a federal service training academy: new implications from an old scenario. Clin Infect Dis. 1999;29:1545-1550.http://www.ncbi.nlm.nih.gov/pubmed/10585810?tool=bestpractice.com
3.5% 到 10% 的社区获得性肺炎病例由肺炎衣原体导致。和肺炎支原体一样,肺炎衣原体感染也主要发生在儿童和年轻人,这些人往往居住在人群聚集的社区中。[1]Marchello C, Dale AP, Thai TN, et al. Prevalence of atypical pathogens in patients with cough and community-acquired pneumonia: a meta-analysis. Ann Fam Med. 2016;14:552-566.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389400/http://www.ncbi.nlm.nih.gov/pubmed/28376442?tool=bestpractice.com[3]Jain S, Williams DJ, Arnold SR, et al; CDC EPIC Study Team. Community-acquired pneumonia requiring hospitalization among US children. N Engl J Med. 2015;372:835-845.http://www.nejm.org/doi/full/10.1056/NEJMoa1405870#t=articlehttp://www.ncbi.nlm.nih.gov/pubmed/25714161?tool=bestpractice.com[5]File TM. Community-acquired pneumonia. Lancet. 2003;362:1991-2001.http://www.ncbi.nlm.nih.gov/pubmed/14683661?tool=bestpractice.com[8]File TM Jr, Tan JS. Chlamydia pneumoniae pneumonia. Semin Respir Critical Care Med. 2000;21:285-294.http://www.ncbi.nlm.nih.gov/pubmed/16088739?tool=bestpractice.com[9]Conklin L, Adjemian J, Loo J, et al. Investigation of a Chlamydia pneumoniae outbreak in a Federal correctional facility in Texas. Clin Infect Dis. 2013;57:639-647.http://www.ncbi.nlm.nih.gov/pubmed/23723194?tool=bestpractice.com荷兰的一项研究对痰(在可用时)进行聚合酶链反应 (polymerase chain reaction, PCR) 检查,发现在 4.8% 的病例中,鹦鹉热衣原体 是引起社区获得性肺炎的病因,高于先前的报告 (2.1%)。[10]Spoorenberg SM, Bos WJ, van Hannen EJ, et al. Chlamydia psittaci: a relevant cause of community-acquired pneumonia in two Dutch hospitals. Neth J Med. 2016;74:75-81.http://www.njmonline.nl/getpdf.php?id=1676http://www.ncbi.nlm.nih.gov/pubmed/26951352?tool=bestpractice.com
嗜肺军团菌导致的社区获得性肺炎的病例比例较低(2.7% 左右),[1]Marchello C, Dale AP, Thai TN, et al. Prevalence of atypical pathogens in patients with cough and community-acquired pneumonia: a meta-analysis. Ann Fam Med. 2016;14:552-566.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389400/http://www.ncbi.nlm.nih.gov/pubmed/28376442?tool=bestpractice.com但在需要住院治疗的病例中,高达 16% 是由于这种病原体所致。嗜肺军团菌肺炎通常与暴露在淋浴或冷却系统中的新的雾化水有关。已知的危险因素包括吸烟、慢性肺疾病、免疫抑制和免疫调节药物。[11]Lanternier F, Tubach F, Ravaud P, et al. Incidence and risk factors of Legionella pneumophila pneumonia during anti-tumor necrosis factor therapy: a prospective French study. Chest. 2013;144:990-998.http://www.ncbi.nlm.nih.gov/pubmed/23744173?tool=bestpractice.com它可能与近期旅行有关,男性更易感。[5]File TM. Community-acquired pneumonia. Lancet. 2003;362:1991-2001.http://www.ncbi.nlm.nih.gov/pubmed/14683661?tool=bestpractice.com[12]Arcavi L, Benowitz NL. Cigarette smoking and infection. Arch Intern Med. 2004;164:2206-2216.http://www.ncbi.nlm.nih.gov/pubmed/15534156?tool=bestpractice.com[13]Den Boer JW, Nijhof J, Friesema I. Risk factors for sporadic community-acquired Legionnaires' disease. A 3-year national case-control study. Public Health. 2006;120:566-571.http://www.ncbi.nlm.nih.gov/pubmed/16707144?tool=bestpractice.com[14]England AC III, Fraser DW, Plikaytis BD, et al. Sporadic legionellosis in the United States: the first thousand cases. Ann Intern Med. 1981;94:164-170.http://www.ncbi.nlm.nih.gov/pubmed/7469207?tool=bestpractice.com病毒(包括流感、腺病毒、呼吸合胞病毒以及其他病毒)可能会引起肺炎,可符合非典型细菌性肺炎的特点,占社区获得性肺炎患者的25%。[15]von Baum H, Schweiger B, Welte T, et al; the THE CAPNETZ STUDY GROUP. How deadly is seasonal influenza associated pneumonia? The German Competence Network for Community-acquired pneumonia (CAPNETZ). Eur Respir J. 2011;37:1151-1157.http://www.ncbi.nlm.nih.gov/pubmed/20817703?tool=bestpractice.com[16]Niederman MS. Viral community-acquired pneumonia: if we do not diagnose it and do not treat it, can it still hurt us? Chest. 2010;138:767-769.http://www.ncbi.nlm.nih.gov/pubmed/20923793?tool=bestpractice.com[17]Mandell LA, Wunderink RG, Anzueto A, et al. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007 Mar 1;44 Suppl 2:S27-72.http://cid.oxfordjournals.org/content/44/Supplement_2/S27.longhttp://www.ncbi.nlm.nih.gov/pubmed/17278083?tool=bestpractice.com[18]Lieberman D, Shimoni A, Shemer-Avni Y, et al. Respiratory viruses in adults with community-acquired pneumonia. Chest. 2010;138:811-816.http://www.ncbi.nlm.nih.gov/pubmed/20363845?tool=bestpractice.com
大约1%的肺炎病例由伯纳特氏立克次体感染所致;然而,在牲畜来源气溶胶的高暴露地区,该病有较高的发病率。这种肺炎在欧洲和加拿大的某些地区更为常见。[19]Marrie TJ. Coxiella burnetii pneumonia. Eur Respir J. 2003;21:713-719.http://www.ncbi.nlm.nih.gov/pubmed/12762362?tool=bestpractice.com
社区获得性肺炎的具体病因可以随季节、地区和年龄而变化。[3]Jain S, Williams DJ, Arnold SR, et al; CDC EPIC Study Team. Community-acquired pneumonia requiring hospitalization among US children. N Engl J Med. 2015;372:835-845.http://www.nejm.org/doi/full/10.1056/NEJMoa1405870#t=articlehttp://www.ncbi.nlm.nih.gov/pubmed/25714161?tool=bestpractice.com[20]Gadsby NJ, Russell CD, McHugh MP, et al. Comprehensive molecular testing for respiratory pathogens in community-acquired pneumonia. Clin Infect Dis. 2016;62:817-823.http://cid.oxfordjournals.org/content/62/7/817.longhttp://www.ncbi.nlm.nih.gov/pubmed/26747825?tool=bestpractice.com[21]Jain S, Self WH, Wunderink RG, et al; CDC EPIC Study Team. Community-acquired pneumonia requiring hospitalization among US adults. N Engl J Med. 2015;373:415-427.http://www.nejm.org/doi/full/10.1056/NEJMoa1500245#t=articlehttp://www.ncbi.nlm.nih.gov/pubmed/26172429?tool=bestpractice.com[22]Dumke R, Schnee C, Pletz MW, et al; Capnetz Study Group. Mycoplasma pneumoniae and Chlamydia spp. infection in community-acquired pneumonia, Germany, 2011-2012. Emerg Infect Dis. 2015;21:426-434.http://wwwnc.cdc.gov/eid/article/21/3/14-0927_articlehttp://www.ncbi.nlm.nih.gov/pubmed/25693633?tool=bestpractice.com