库欣综合征

Osilodrostat

这是一种当前正在研究的治疗库欣病的强效口服 11-β-羟化酶抑制剂，它在降低 24 小时尿液游离皮质醇方面显示出令人满意的结果。[116]Bertagna X, Pivonello R, Fleseriu M, et al. LCI699, a potent 11β-hydroxylase inhibitor, normalizes urinary cortisol in patients with Cushing's disease: results from a multicenter, proof-of-concept study. J Clin Endocrinol Metab. 2014 Apr;99(4):1375-83.https://academic.oup.com/jcem/article-lookup/doi/10.1210/jc.2013-2117http://www.ncbi.nlm.nih.gov/pubmed/24423285?tool=bestpractice.com[117]Fleseriu M, Pivonello R, Young J, et al. Osilodrostat, a potent oral 11β-hydroxylase inhibitor: 22-week, prospective, phase II study in Cushing's disease. Pituitary. 2016 Apr;19(2):138-48.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4799251/http://www.ncbi.nlm.nih.gov/pubmed/26542280?tool=bestpractice.com